Data from animal models, historical cohorts, and modern epidemiologic studies have suggested that maternal characteristics can affect reproductive health of offspring; however, distinguishing between prenatal and postnatal contributions is difficult. Anogenital distance (AGD), the distance from the anus to the genitals, is believed to be a biomarker of prenatal androgen exposure in many species...

A 51 year old female presented with a chief complaint of hematochezia, dyschezia, tenesmus and stool incontinence. She also reported a sixmonth history of constipation and pencil thin stools. A colonoscopy demonstrated a near-circumferential friable and bulky rectal mass 4–5 cm from the anal verge (Fig. 1). Biopsy of the mass revealed a moderately differentiated adenocarcinoma presumed to be of...

In 68 patients with anorectal malformations cardiovascular anomalies (CVA) were seen in 15 and genitourinary (GU) anomalies in 30. CVA were more frequent (33%) whenever there was a GU anomaly. Ventricular septal defect was the most frequent lesion. All but 1 CVA occurred with type III anorectal malformation. The complexity of the cardiac lesion did not parallel that of the GU anomaly.

On the 23rd January, 1923, while I was in charge of the Local Fund Dispensary at Sorah, a female child aged 6 months, was brought to me with a history that the child had no anus at all from birth and that small quantities of liquid fsecal matter occasionally escaped from the vagina. Since the child was not in any way inconvenienced, the parents did not mind this abnormality. During the last for...

AbstractBackground Anteriorly displaced anus (ADA) is defined as anterior displacement of the toward perineum. Early radiologic characterization a crucial step in guiding first-line management. Objective The objective this study was to assess urethra-to-anus distance (UAD) on perineal ultrasound female infants under age 3 months with anteriorly and retrospectively det...

Anal cancer is a relatively rare gastrointestinal tumor with roughly 7,000 new cases per year. Metastatic anal cancer as an initial presentation occurs in 10-20% of the patients. Treatment for localized disease is well established with concurrent chemoradiation (CCR) therapy as the standard of care; however, metastatic anal cancer remains a therapeutic challenge. National Comprehensive Cancer N...