The aim of this study was to further characterize pharmacological properties of two phenylpiperazine derivatives: 1-{2-[2-(2,6-dimethlphenoxy)ethoxy]ethyl}-4-(2-methoxyphenyl)piperazynine hydrochloride (HBK-14) and 2-[2-(2-chloro-6-methylphenoxy)ethoxy]ethyl-4-(2- methoxyphenyl)piperazynine dihydrochloride (HBK-15) in radioligand binding and functional in vitro assays as well as in vivo models....

background research in the area of herbal psychopharmacology has clearly improved in recent decades. self-administration of herbal medicines has been the most popular therapeutic alternative to standard medicine. objectives since the extract of echium amoenum exhibits an anxiolytic effect, the aim of this study is to evaluate the anxiolytic and hypnotic effects in mice of the aqueous and ethano...

introduction: in this study, we investigated the role of n-methyl-d-aspartate (nmda) receptors in the ventral hippocampus (vh) and their possible interactions with gabaa system on anxiety-like behaviors. methods: we used an elevated-plus maze test (epm) to assess anxiety-like behaviors and locomotor activity in male wistar rats. results: the results showed that intra-vh infusions of different d...

The biochemical and behavioral effects of a nonpeptidic, selective, and brain-penetrant agonist at the ORL1 receptor are reported herein. This low molecular weight compound [(1S,3aS)-8- (2,3,3a,4,5, 6-hexahydro-1H-phenalen-1-yl)-1-phenyl-1,3,8-triaza- spiro[4. 5]decan-4-one] has high affinity for recombinant human ORL1 receptors and has 100-fold selectivity for ORL1 over other members of the op...

OBJECTIVE The aim of this study is to investigate the antidepressant and anxiolytic effects of simvastatin in rats. METHODS Sixty-four male adult (8-9 weeks old) Sprague-Dawley rats (200-250 g) were used. The forced swimming test and the elevated plus maze test were used for testing the antidepressant and anxiolytic effects. Eight groups were formed: control (saline), simvastatin 10, 30, and ...

INTRODUCTION Previous studies have shown that the cannabinoid system is involved in anxiety. In addition, transient receptor potential vanilloid type-1 (TRPV1) channels are new targets for the development of anxiolytics. The present study investigated the possible interaction between the cannabinoid and vanilloid systems on anxiety-like behavior in rats. METHODS Four different groups of male ...