Recurrent Aphthous Stomatitis (RAS) is a disorder characterized by recurring ulcers in the oral mucosa in patients with no other signs of disease. This condition is also called as Sutton’s disease, especially in the case of major, multiple or recurring ulcers. RAS appears to represent several pathological states with similar clinical manifestations, including immunologic disorders, hematologic ...

Introduction Recurrent aphthous stomatitis (RAS) is a common chronic inflammatory oral mucosa disease with an unknown cause. However, dysregulation of the immune response seems to play an important role in this disease. Aim To evaluate the vitamin D status in RAS patients and its effects on RAS severity, given the likely immunomodulatory function of vitamin D in the human organism. Material...

Diverticulitis is a well-established complication of diverticulosis. Data regarding the endoscopic appearance of diverticulitis are limited, as colonoscopy is generally contraindicated during the acute attack, due to the increased risk of complications, especially bowel perforation. Endoscopic signs of inflammation in patients with diverticulosis are limited to the segments having the diverticu...

Most mouth ulcers are caused by trauma or are aphthous. Nevertheless, they may be a manifestation of a wide range of mucocutaneous or systemic disorders, including infections, drug reactions, and disorders of the blood and gastro-intestinal systems, or they may be caused by malignant disease. The term mouth ulcers should not, therefore, be used as a final diagnosis. An ulcer may develop from mi...

A variety of extraintestinal manifestations, probably immune-mediated, may appear during relapses of Crohn's disease. We report the clinical observation of a 34-year-old woman who developed a Guillain-Barré syndrome, aphthous stomatitis and oligoarthritis during a relapse of Crohn's ileocolitis. This case suggests that the Guillain-Barré syndrome may be another extraintestinal manifestation of ...

We describe an 18-year-old man with a 7-year history of severe major aphthous stomatitis refractory to multiple standard therapies who responded completely to therapy with adalimumab, a fully humanized monoclonal antibody against tumor necrosis factor alpha (TNF-alpha).

Mukhapaka (Stomatitis) is a common ailment seen in general practice. The Pittaja (Aphthous ulcer) fully described Ayurveda under the term Mukha rogas. Oral ulcers are estimated to impact 4% of global population, with aphthous being most frequent, affecting up 25% population. Psychological stress, hormonal impacts, dietary sensitivity, and nutritional insufficiency primary causes ulcer). It pain...

Patients with Behçet's disease may develop multiple mucocutaneous manifestations, several of which are mediated by neutrophils. These include aphthous ulcers, pseudofolliculitis, acneform lesions, and pathergy. We report another neutrophil-mediated disorder, neutrophilic eccrine hidradenitis (NEH), in a patient with Behçet's disease. NEH should be added to the list of mucocutaneous lesions that...