BACKGROUND Via sequencing the genes of apelin/angiotensin receptor-like 1 (apelin/APJ) pathway, we have recently identified and validated four common polymorphisms (rs3761581, rs56204867, rs7119375, and rs10501367) implicated in the development of hypertension. Extending these findings, we, in Chinese hypertensive patients, sought to investigate the association of these four polymorphisms and o...

Apelin, a peptide hormone, is an endogenous ligand for G protein-coupled receptor and has been shown to be widely expressed in human animal tissues, such as the central nervous system adipose tissue. Recent studies indicate that apelin/APJ involved regulation of multiple physiological pathological processes, it associated with cardiovascular diseases, metabolic disorders, neurological ischemia-...

We infer the normalization and the radial and angular distributions of the number density of satellites of massive galaxies (log10[M*h/M �] > 10.5) between redshifts 0.1 and 0.8 as a function of host stellar mass, redshift, morphology, and satellite luminosity. Exploiting the depth and resolution of the COSMOS Hubble Space Telescope images, we detect satellites up to 8 mag fainter than the host...

Angiotensin-converting enzyme 2 (ACE2)/Ang II/Ang 1-7 and the apelin/APJ are two important peptide systems which exert diverse effects on the cardiovascular system. ACE2 is a key negative regulator of the renin-angiotensin system (RAS) where it metabolizes angiotensin (Ang) II into Ang 1-7, an endogenous antagonist of Ang II. Both the prolonged activation of RAS and the loss of ACE2 can be detr...

This manuscript is an updated version of Kalogera et al. (2004) published in ApJ Letters to correct our calculation of the Galactic DNS coalescence rate. The details of the original erratum submitted to ApJ Letters are given in page 6 of this manuscript. We report on the newly increased event rates due to the recent discovery of the highly relativistic binary pulsar J0737–3039 (Burgay et al. 20...

Apelin is the endogenous ligand of APJ, which belongs to the family of G protein‑coupled receptors. Apelin and APJ are highly expressed in various cardiovascular tissues, including the heart, kidney and vascular endothelial and smooth muscle cells. Although apelin exerts hypotensive effects via activation of endothelial nitric oxide synthase (eNOS), the ability of apelin to regulate blood press...