نتایج جستجو برای: apoptotic

تعداد نتایج: 50280  

Journal: :Journal of Investigative Dermatology 2023

Pemphigus vulgaris (PV), a severe mucocutaneous blistering disease, results from autoantibody-mediated destabilization of epidermal cell-cell adhesion. A functional risk variant at the ST18 locus was found to promote expression. Increased expression aggravate deleterious effect PV autoantibodies in part through induction p53-mediated pro-apoptotic pathways. Global RNA sequencing human keratinoc...

2016
Prajwal Gurung

Billions of cells die everyday as a result of normal tissue turnover, infection, trauma or injury. These dead cells are taken up, processed and presented to T cells by antigen presenting cells resulting in tolerance or immunity. Apoptotic cells induce tolerance; however, the precise mechanisms are still unknown. Previous studies have shown that direct infusion of apoptotic cells induce toleranc...

Journal: :American journal of physiology. Lung cellular and molecular physiology 2012
Mark T Kearns Samay Dalal Sarah A Horstmann Tiffany R Richens Takeshi Tanaka Jenna M Doe Darren M Boe Norbert F Voelkel Laimute Taraseviciene-Stewart William J Janssen Chun G Lee Jack A Elias Donna Bratton Rubin M Tuder Peter M Henson R William Vandivier

Efficient clearance of apoptotic cells from the lung by alveolar macrophages is important for the maintenance of tissue structure and function. Lung tissue from humans with emphysema contains increased numbers of apoptotic cells and decreased levels of vascular endothelial growth factor (VEGF). Mice treated with VEGF receptor inhibitors have increased numbers of apoptotic cells and develop emph...

Journal: :Anti-cancer Agents in Medicinal Chemistry 2021

Background: Syzygium cumini is one of the evidence-based traditional medicinal plant used in treatment various ailments. Objectives: Herein, antioxidant property and anticancer against Ehrlich Ascites Carcinoma (EAC) cells were examined to find effective chemotherapeutics. Methods: In vitro assays, phytochemical chromatographic analyses determine properties chemical constituents cummini Bark Me...

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