The objective of this study was to determine the effects and mechanisms of serum amyloid A (SAA) on coronary endothelial function. Porcine coronary arteries and human coronary arterial endothelial cells (HCAECs) were treated with SAA (0, 1, 10, or 25 microg/ml). Vasomotor reactivity was studied using a myograph tension system. SAA significantly reduced endothelium-dependent vasorelaxation of po...

We reported a procedure of serum anticholinergic activity (SAA) measurement and the reliability and reproducibility of the receptor binding assay, and we also described the usefulness of SAA measurement reflecting the anticholinergic activity (AA) in the central nervous system (CNS). According to the results of a 10 times repeated measurement of standard atropine binding, the relative error was...

The serum amyloid protein (apo-SAA) is a unique high density lipoprotein apoprotein exhibiting dramatic increases in plasma concentration following host injury. The events involved in the secretion of apo-SAA and assembly of apo-SAA-rich lipoprotein particles were studied in primary, serum-free culture of adult BALB/c mouse hepatocytes harvested 3 h following administration of the potent apo-SA...

In this paper, we describe the system we developed for the SemEval-2010 task of disambiguating sentiment ambiguous adjectives (hereinafter referred to SAA). Our system created a new word library named SAA-Oriented Library consisting of positive words, negative words, negative words related to SAA, positive words related to SAA, and inverse words, etc. Based on the syntactic parsing, we analyzed...

Serum amyloid A (SAA) is an acute-phase protein, the serum levels of which can increase up to 1000-fold during inflammation. SAA has a pathogenic role in amyloid A-type amyloidosis, and increased serum levels of SAA correlate with the risk for cardiovascular diseases. IL-1β is a key proinflammatory cytokine, and its secretion is strictly controlled by the inflammasomes. We studied the role of S...

BACKGROUND Obesity is associated with low-grade chronic inflammation, and serum markers of inflammation are independent risk factors for cardiovascular disease (CVD). However, the molecular and cellular mechanisms that link obesity to chronic inflammation and CVD are poorly understood. METHODS AND FINDINGS Acute-phase serum amyloid A (A-SAA) mRNA levels, and A-SAA adipose secretion and serum ...

Periodic occupational health examinations often require venepuncture. Acute psychological and physical stressors during such procedure result in sympathetic stimulation and increased salivary protein secretion, including salivary α-amylase (SAA). We studied SAA response to venepuncture during such examination. Fifty-eight healthy males undergoing periodic medical examination reported perceived ...

Most notable among the acute phase proteins is serum amyloid A (SAA), levels of which can increase 1000-fold during infections, aseptic inflammation, and/or trauma. Chronically elevated SAA levels are associated with a wide variety of pathological conditions, including obesity and rheumatic diseases. Using a recombinant hybrid of the two human SAA isoforms (SAA1 and 2) that does not exist in vi...

Background: Nasopharyngeal carcinoma (NPC) remains as a devastating malignancy due to a lack of effective therapy for recurrence and metastasis. Salvianolic acid A (SAA), a compound extracted from Salvia miltiorrhiza, possesses a variety of biological properties such as antioxidant, antithrombotic, myocardial ischemia protection and anti-hepatic-fibrosis. However, the effect of SAA on NPC cells...

The disassembly is a fundamental basis in converting End-of-Life (EOL) products into useful components. Related research becomes popular recently due to the increasing awareness of environmental protection and energy conservation. Yet, there are many opening questions needed be investigated, especially efficient coordination different-level decisions under uncertainty big challenge. In this pap...