Micro-organisms may simultaneously encounter multiple stresses in their environment. To investigate the protection that several known Escherichia coli O157 : H7 acid-resistance systems might provide against both oxidative and acid stress, the addition of diamide, a membrane-permeable thiol-specific oxidizing agent, or hydrogen peroxide were used concurrent with acid challenge at pH 2.5 to deter...

The design of a multi-subject fMRI experiment needs specification of the number of subjects and scanning time per subject. For example, for a blocked design with conditions A or B, fixed block length and block order ABN, where N denotes a null block, the optimal number of cycles of ABN and the optimal number of subjects have to be determined. This paper presents a method to determine the optima...

mathematical models have the potential to provide a cost-effective, objective, and flexible approach to assessing management decisions, particularly when these decisions are strategic alternatives. in some instances, mathematical model is the only means available for evaluating and testing alternatives.  however, in order for this potential to be realized, models must be valid for the applicati...

Khalatbary AR1, Tarihi T2, Naderimanesh H3 1. Assistant Professor, Department of Anatomy, Faculty of Medicine, Lorestan University of Medical Sciences 2. Professor, Department of Anatomy, Faculty of Medicine, Ttarbiat Modarres University , Tehran 3. Professor, Department of Biophysics, Faculty of Basic Sciences, Tarbiat Modarres University , Tehran Abstract Background: Apoptosis is an active ...

Human transient receptor potential ankyrin channel 1 (TRPA1) is a polymodal sensor implicated in pain, inflammation and itching. An important locus for TRPA1 regulation is the cytoplasmic N-terminal domain, through which various exogenous electrophilic compounds such as allyl-isothiocyanate from mustard oil or cinnamaldehyde from cinnamon activate primary afferent nociceptors. This major region...

GerE from Bacillus subtilis is the smallest member of the LuxR-FixJ family of transcription activators. Its 74-amino-acid sequence is similar over its entire length to the DNA binding domain of this protein family, including a putative helix-turn-helix (HTH) motif. In this report, we sought to define regions of GerE involved in promoter activation. We examined the effects of single alanine subs...

The spider Macrothele raveni was recently identified as a new species of Genus Macrothele. The crude venom from M. raveni was found to be neurotoxic to mice and the LD(50) of the crude venom in mice was 2.852mg/kg. Two neurotoxic peptides, raventoxin-I and raventoxin-III, were isolated from the crude venom by ion-exchange and reverse phase high performance liquid chromatography. Raventoxin-I wa...

Enhanced ceramide glycosylation catalyzed by glucosylceramide synthase (GCS) limits therapeutic efficiencies of antineoplastic agents including doxorubicin in drug-resistant cancer cells. Aimed to determine the role of GCS in tumor response to chemotherapy, a new mixed-backbone oligonucleotide (MBO-asGCS) with higher stability and efficiency has been generated to silence human GCS gene. MBO-asG...

In this paper a simple algorithm for adaptation of the complex baseband weights of a transmit antenna array using feedback from the receiver is proposed and analyzed. The system utilizes stochastic gradient adaptation to maximize the power delivered to the receiver for a constrained transmission power, which provides both fading diversity and beam steering gain. Dual perturbed transmission weig...

A interação entre três corantes aniônicos azo: C.I. Vermelho Ácido 14 (AR14), C.I. Vermelho Ácido 1 (AR1), C.I. Laranja Ácido 7 (AO7) e um surfactante catiônico, o brometo de tetradeciltrimetilamônio (TTAB), foi investigada por meio da técnica de eletrodo seletivo para surfactante. O eletrodo seletivo para TTAB foi construído e usado para determinar a concentração de monômeros TTAB e, também, d...