background: arsenic toxicity is a major global health problem and exposure via contaminated drinking water has been associated with hematological and other systemic disorders. the present investigation has been conducted in adult male rats to evaluate the protective ability of α-lipoic acid (ala) against such hematological disorders. methods: twenty-four adult male wister rats (b.wt.130±10g) we...

Exposure to toxic metals remains a widespread occupational and environmental problem in world. There have been a number of reports in the recent past suggesting an incidence of childhood lead poisoning and chronic arsenic poisoning due to contaminated drinking water in many areas of West Bengal in India and Bangladesh has become a national calamity. Low level metal exposure in humans is caused ...

a toxic metalloid, affects millions of people worldwide, mainly from drinking contaminated water. Arsenic is a human carcinogen that targets skin, lung, bladder, and possibly other sites. iAs and its methylated metabolites readily cross the placenta and reach the fetus [National Research Council (NRC) 1999], producing effects ranging from developmental toxicity to cancer (NRC 1999; Waalkes et a...

Arsenic contamination of groundwater in low-lying Bhagarathi–Ganga deltaic plain is known for more than two decades. The problem was recognized in 1984 (ref. 1) in West Bengal, when 16 patients from a village of 24 Parganas district reported arsenicosis. Subsequent investigations revealed extensive arsenic contamination in groundwater in the Bengal Basin affecting the eastern part of West Benga...

Humans are exposed to arsenic (As) primarily from air, food and water. However, elevated inorganic As in drinking water is the major cause of As toxicity. Most of the reports of chronic As toxicity in man focus attention on skin manifestations because of its diagnostic specificity, but As often affects most systems of the body. The clinical manifestations of chronic As intoxication are dependen...

a Department of Public Health and the Environment, World Health Organization, 20 avenue Appia, 1211 Geneva 27, Switzerland. Correspondence to Jamie Bartram (e-mail: [email protected]). doi:10.2471/BLT.07.049619 Despite long-standing evidence that water sanitation and hygiene are fundamental to health, health institutions have become distanced from water and sanitation since the 1970s. In develop...

Under the section results, the last sentence is not useful. The p value can be added to the previous sentence. We changed the text as you suggested (page 2). We also deleted the last sentence as suggested. Under the section conclusions: I suggest the following: The study showed a statistically significant association between chronic exposure to arsenic and age of menopause. Heavily exposed wome...