نتایج جستجو برای: arterial drug injection
تعداد نتایج: 844902 فیلتر نتایج به سال:
Understanding the effects of inflammation and cirrhosis on regulation drug metabolism during progression hepatocellular carcinoma (HCC) is critical for developing patient-specific treatment strategies. Herein, novel 3D vascularized HCC chips (HCCoCs), composed HCC, endothelial, stellate, Kupffer cells tuned to mimic normal or cirrhotic liver stiffness, are created. controlled by tuning macropha...
Prostacyclin synthase (PGIS) is the final committed enzyme in the metabolic pathway of prostacyclin production. The therapeutic option of intravenous prostacyclin infusion in patients with pulmonary arterial hypertension is limited by the short half-life of the drug and life-threatening catheter-related complications. To develop a better delivery system for prostacyclin, we examined the feasibi...
The aim of this study was to determine whether 5-HT2A receptors mediate cardiovascular and thermogenic responses to acute psychological stresses. For this purpose, adult male Wistar hooded rats instrumented for telemetric recordings of either electrocardiogram (ECG) (n=12) or arterial pressure (n=12) were subjected, on different days, to four 15-min episodes of social defeat. Prior to stress, a...
delivery of exogenous materials such as nucleic acids, peptides, proteins, and drugs into cells is an important strategy in modern cellular and molecular biology. recently, the development of gene carriers for efficient gene transfer into cells has attracted a great attention. furthermore, lack of effective drug delivery is one of the major problems of cancer chemotherapy. many physical methods...
We present an elbow disarticulation due to accidental intra-arterial injection of diazepam. Considering the risk of inadvertent and accidental intra-arterial injection of diazepam and its subsequent severe sequelae that are reported in the literature, we emphasize that intravenous diazepam should be administered with more hesitancy and care.
Baroreceptor reflex is an important system for neural control of blood pressure. Recently, reactive oxygen species (ROS) have been shown to play an important role in neuronal activity of central areas related to blood pressure control. The aim of this study was to investigate the effects elicited by ascorbic acid (AAC) and N-acetylcysteine (NAC) injections into the 4thV on the parasympathetic c...
The central and peripheral cardiovascular effects of endothelin (ET)-1 and ET-3 were investigated in conscious rainbow trout. Both intracerebroventricular and intra-arterial injections of ET-1 (6.25-25 pmol) but not ET-3 (25 pmol) caused a dose-dependent increase in mean dorsal aortic blood pressure and a concomitant decrease in heart rate. The hypertensive effects induced by intra-arterial and...
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