A noncontrast electrocardiography (ECG)-gated, fast-spin-echo magnetic resonance imaging was applied to noninvasively define perfusion impairments in pulmonary embolic and airway obstruction dog models. Two-phase ECG-gated lung images of the minimal lung signal intensity during systole and maximal signal intensity during diastole were acquired by using optimized R-wave triggering delay times in...

Chronic thromboembolic pulmonary hypertension (CTEPH) is characterised by proximal pulmonary vascular obstruction by thrombo-fibrotic material, the origin of which has not been elucidated. Enhanced inflammation could contribute to persistent obstruction by impairing pulmonary vascular cell function in CTEPH. We investigated C-reactive protein (CRP) effects on pulmonary vascular cell function in...

Bubbles introduced to the arterial circulation during invasive medical procedures can have devastating consequences for brain function but their effects are currently difficult to quantify. Here we present a Monte Carlo simulation investigating the impact of gas bubbles on cerebral blood flow. For the first time, this model includes realistic adhesion forces, bubble deformation, fluid dynamical...

This study was designed to investigate the relationship between the different clinical features exhi,bited by patients with chronic airways obstruction and their responsiveness to carbon dioxide. In 19 patients pulmonary function was assessed by spirometry, lung volumes and arterial blood gases. Measurements of responsiveness to carbon dioxide were made and compared with responses obtained in f...

G ANGRENE of an extremity caused by venous occlusion without associated arterial occlusion is uncommon. Haimovicil noted that Fabricus Hildanus, in 1593, apparently recognized the possibility of gangrene of venous origin; it was not until 1859, however, that Heuter2 reported a case, giving an excellent account of the clinical and pathologic criteria of this type of gangrene. Gregoire,3 in 1938,...

Alagille syndrome is an autosomal dominant disorder that caused by heterozygous mutation of JAG1 or NOTCH2 gene impacts several multisystem organs including but may not be limited to the liver, heart, musculoskeletal, skin, and eyes. The most common congenital heart defect associated with multilevel right ventricular outflow tract obstruction multiple central peripheral branch pulmonary arteria...

G ANGRENE of an extremity caused by venous occlusion without associated arterial occlusion is uncommon. Haimovicil noted that Fabricus Hildanus, in 1593, apparently recognized the possibility of gangrene of venous origin; it was not until 1859, however, that Heuter2 reported a case, giving an excellent account of the clinical and pathologic criteria of this type of gangrene. Gregoire,3 in 1938,...

G ANGRENE of an extremity caused by venous occlusion without associated arterial occlusion is uncommon. Haimovicil noted that Fabricus Hildanus, in 1593, apparently recognized the possibility of gangrene of venous origin; it was not until 1859, however, that Heuter2 reported a case, giving an excellent account of the clinical and pathologic criteria of this type of gangrene. Gregoire,3 in 1938,...

Chronic obstructive pulmonary disease (COPD) is associated with cardiovascular morbidity and mortality. Arterial stiffness and endothelial dysfunction index are validated surrogate cardiovascular markers and are increased in subjects with COPD. We tested whether increased arterial stiffness and endothelial dysfunction occur in symptomatic smokers with no evidence of bronchial obstruction. Clini...

This study was designed to test the hypothesis that the medullary lateral tegmental field (LTF) is an important synaptic relay in the baroreceptor reflex pathway controlling sympathetic nerve discharge (SND) of urethan-anesthetized cats. We determined the effects of blockade of excitatory amino acid-mediated neurotransmission in the LTF on three indexes of baroreceptor reflex function: cardiac-...