The Aristolochia bracteata is well known for its antiarthritis properties in Indian system of medicine and folk medicine. The objective of the present study was to evaluate its folk claim in rheumatoid arthritis (RA) and propose a probable mechanism of action. Anti arthritic activity was evaluated using Freund’s complete adjuvant in rats, the course of treatment was followed for over and 4 week...

Over 90% of the population will suffer from arthritis during their lifetime but present treatment regimens cannot completely abrogate chronic episodes of inflammation, pain, or disability. This costs an estimated 60 billion dollars/year in total costs of medicines, disability and lost wages (Arthritis Foundation, 2002). It is firmly accepted that neurogenic factors play a role in peripheral inf...

Rheumatoid arthritis is a chronic inflammatory joint disease characterized by synovial proliferation and tissue destruction. Proinflammatory cytokines like interleukin-1beta (IL-1β) and tumor necrosis factor-alpha (TNF-α) play a key role in the disease process and elevate energy expenditure, which further increases the joint pain and stiffness. To explore the effects of N-(2-hydroxyphenyl) acet...

Rheumatoid cachexia is associated with rheumatoid arthritis and it increases mortality and morbidity. Adjuvant-induced arthritis is an experimental model of rheumatoid arthritis that causes anorexia and muscle wasting. α-Melanocyte-stimulating hormone (α-MSH) has anti-inflammatory actions, and it is able to decrease inflammation in several inflammatory diseases including experimental arthritis....

The anti-diabetic and anti-arthritic potential of the ethonolic extract of stem bark of Glycosmis pentaphylla (Rutaceae), a medicinal plant widely used in the traditional Ayurveda and siddha systems of medicine for the treatment by the streptozotocin induced diabetic model and anti-arthritic activity was evaluated by FCA induced arthritis for separate group of animals. Graded doses of the ethon...