Ascorbic acid and Mg-ATP were found to regulate norepinephrine biosynthesis in intact secretory vesicles synergistically and specifically, using the model system of isolated bovine chromaffin granules. Dopamine uptake into chromaffin granules was shown to be unrelated to the presence of Mg-ATP and ascorbic acid at external dopamine concentrations of 7.5 and 10 mM. Under these conditions of dopa...

BACKGROUND Ascorbic acid reduced the severity of neuropathy in transgenic mice overexpressing peripheral myelin protein 22 (PMP22), a model of Charcot-Marie-Tooth disease type 1A (CMT1A) associated with the PMP22 duplication. However, in three 1-year trials, ascorbic acid had no benefit in human beings. We did a multicentre 2-year trial to test the efficacy and tolerability of ascorbic acid in ...

on the urinary excretion of ascorbic acid in health and disease. Now the study of plasma level of ascorbic acid has been made. References in the literature on the plasma concentration of ascorbic acid in health and disease are few but none of them tries to ascertain relationship of plasma ascorbic acid to any disease factors or blood pictures. Richeri and Litter (1939) coneluded from their stud...

Background & Aims: Stroke is the third leading cause of death. Oxidative stress has a principal role in the complications of stroke. Due to this fact and the antioxidant effects of ascorbic acid, this study was designed to evaluate the effect of ascorbic acid on reduction of stroke complications in a permanent model of middle cerebral artery (MCA) occlusion in male rats. Methods: In this experi...

osteoporosis is a silent epidemy of today's world, and is also a prevalent problem of health in iran. the role of nutrients such as ascorbic acid, a key antioxidant vitamin, in this disease has recently attracted researchers' attention. in this study, we studied the relation between plasma ascorbic acid concentration and bone mineral density (bmd) in women referring to jami clinic, te...

The actions of the reductant ascorbic acid on rat neocortical neurons in vitro was investigated by means of intracellular recordings. At a concentration (500 microM), which reduced the magnitude of dopamine degradation in oxygen-saturated saline solutions by about 50%, ascorbic acid reversibly depressed synaptic potentials and enhanced direct excitability of cortical neurons. The latter effect ...

1. Ascorbic acid was absorbed across the mucosa of the human mouth. 2. Omission of sodium ions from the medium decreased the absorption of ascorbic acid. 3. The presence of D-glucose, or 3-O-methyl-D-glucose, increased the absorption of ascorbic acid but D-fructose had little effect and D-mannitol had no effect. 4. Calcium ions also increased ascorbic acid absorption probably by a secondary ef...

Warfarin and Ascorbic Acid: Lack of Evidence for a Drug Interaction. WEINTRAUB, M. AND GRINER, P. F. (1974). Toxicol. Appl. Pharmacol. 28, 53-56. The effects of high-dose ascorbic acid on warfarin-induced hypoprothrombinemia and clotting factor activity kinetics were studied in healthy dogs. The biologic half-life and rates of synthesis of these factors were unaffected by ascorbic acid. No chan...