It was first demonstrated by Kidd (4) in 1953 that the growth of certain lymphosarcomas of rats and mice could be suppressed by treatment with guinea pig serum. In 1961, Broome (1) identified the lymphosarcoma-inhibitory factor as the enzyme L-asparagine aminohydrolase, EC 3.5.1.1 (L-asparaginase). Recently, Kidd and Sobin (5) showed that lymphosarcoma 6C3HED cells growing intraperitoneally in ...

Abstract Tumor cells have different metabolism from normal cell, which is called as cancer metabolism. In cells, asparagine provided by synthetase (ASNS) aspartate. On the other hand, in tumor needed to be taken outside addition synthesized ASNS within because of rapid growth cells. Glioblastoma one aggressive brain tumors, and temozolomide frequently used. After glioblastoma acquire resistance...

BACKGROUND AND OBJECTIVES Pegylated-asparaginase (PEG-ASP) has been traditionally used as a second-line preparation in children with acute lymphoblastic leukemia (ALL) presenting with clinical allergy to native asparaginase (ASP) products. The main goal of the present study was to investigate the pharmacological effects of the administration of PEG-ASP given as a first-line product in children ...

The enzyme L-asparaginase (L-asparagine amidohydrolase) catalyzes the breakdown of L-asparagine into aspartate and ammonia, which leads to an anti-neoplastic activity stemming from its capacity deplete concentrations in bloodstream, it is therefore used cases acute lymphoblastic leukemia (ALL) inhibit malignant cell growth. Nowadays, this anti-cancer enzyme, largely produced by Escherichia coli...

In the title compound, C(11)H(14)N(2)O(5)S, the amide O atom acts as a hydrogen-bond acceptor from a carboxyl-ate O atom and a secondary amino N atom. In addition, one of the sulfonyl O atoms and the carbonyl O atom of the carboxyl group also form hydrogen bonds with the primary amido N atom. These intermolecular hydrogen-bonding inter-actions give rise to a layer structure, with the layers par...

The presence of acrylamide, a mutagen and Group 2A carcinogen, in food, is health concern that might raise cancer risk. Acrylamide mainly formed the Maillard reaction between free asparagine reducing sugars, during industrial thermal food processing or home cooking, at temperature over 120°C. European Commission Regulation (EU) 2017/2158 established mitigation measures benchmarks for acrylamide...

The tendency to consume food with lower sugar content and alternatively healthy foods and food products are rising. High levels of sugar in date syrup might be used as a good alternative to sugar in various food products. Iran is one of the main producers of date fruit and it is possible to produce foods with high nutritional values from date to replace high-sugar content food....

One dominant structure has been identified analysing the rotational spectrum of asparagine in sharp contrast with the multiconformational behaviour for other amino acids with polar side chains. This locking of the conformational variety to a single conformer has been ascribed to an intramolecular hydrogen bonding network involving α-amine, α-carboxylic and amide groups.

A simple and efficient synthesis of N-linked glycoamino acids and glycopeptides from deprotected sugars using the Staudinger reaction.