Nonalcoholic fatty liver disease (NAFLD) is often associated with dyslipidemia. Metabolic disequilibrium, resulting from being overweight and obesity, increases risk to cardiovascular system and chronic liver disease. Alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyl transferase (GGT) are standard clinical markers for liver injury. In this study, we examined as...

To assess the utility of the serum aspartate aminotransferase/alanine aminotransferase (AST/ALT) ratio in a group of infants with liver disorders, we retrospectively analyzed the charts of 73 infants with chronic liver disorders. Patients were considered as having either a good outcome (n = 40) or a poor outcome (n = 33), based upon the clinical course. AST and ALT in serum were measured simult...

Arginine catabolism produces ammonia without transferring nitrogen to another compound, yet the only known pathway of arginine catabolism in Escherichia coli (through arginine decarboxylase) does not produce ammonia. Our aims were to find the ammonia-producing pathway of arginine catabolism in E. coli and to examine its function. We showed that the only previously described pathway of arginine ...

Elevation in liver transaminases is common in patients treated with the marine antitumor agent trabectedin. However, the impact of trabectedin-related transaminase elevations on treatment outcomes is unclear. This retrospective study investigated the correlation between liver tests abnormalities and treatment outcomes in patients with unresectable advanced or metastatic soft tissue sarcomas (ST...

OBJECTIVES The incidence of non-alcoholic fatty liver disease (NAFLD) is significant in hepatitis C virus (HCV) carriers due to multiple mechanisms, and this worsens the progression of chronic liver diseases, such as cirrhosis and hepatocellular carcinoma, and death. The purpose of this study was to examine whether the alanine aminotransferase/aspartate aminotransferase (ALT/AST) ratio correlat...

Background: Method verification is a one-time process to determine performance characteristics before a test system is utilized for patient testing. Objective: To evaluate the analytical performance of five analytes-glucose (glu), cholesterol (chol), creatinine (crea), aspartate aminotransferase, (AST) and alanine aminotransferase (ALT) on AU 480 Beckman Coulter clinical chemistry analyzer. Met...

hydatid disease is caused by the larva of echinococcus granulosus parasite. mebendazole (mbz) is used as an alternative choice for the treatment of the disease. aspartate aminotransferase (ast) is an essential enzyme in amino acid metabolism. the aim of the present study is to evaluate the effect of mbz on ast activity of hydatid cyst parasite in order to detect enzymatic parameter for drug eff...

The aim of the present study was to investigate effect antihistamines(Chlorpheneramineand Fexofenadine) on (alkaline phosphatase, aspartate amino transpherase and alanine transferase) in tissue fertilized hens eggs embryos as indicator damage. injection hen's with antihistamines Fexofenadine at 12th day incubation doses (0,5,0,1mg/ egginto air sell)after 24 hour treatment induce significantly d...

BACKGROUND A detrimental interaction between smoking and alcohol consumption with respect serum γ-glutamyltransferase (γ-GT) has recently been described. The underlying mechanisms remain unknown. The present work aimed to provide further insights by examining similar interactions pertaining to aspartate and alanine transaminase (AST, ALT), routine liver markers less prone to enzyme induction. ...

BACKGROUND The aim of this study was to evaluate the associations between alanine aminotransferase (ALT) and aspartate aminotransferase (AST) with metabolic syndrome (MetS) in the general Chinese population. METHODS This study was a multicenter, cross-sectional study which was conducted in rural areas of China from the 2012 to 2013 Northeast China Rural Cardiovascular Health Study (NCRCHS), a...