Background Recent studies using single cell RNA sequencing have delineated distinct subpopulations of fibroblasts in skin and other organs. To improve understanding functional differences between fibroblast subpopulations, we developed a novel technique to selectively isolate “migratory” fibroblasts, non-migratory “resident” from heathy control (HC) SSc skin. Objectives compare migratory reside...

In this study, we considered progression of liver diseases. Particularly Hepatocellular Carcinoma Cancer, HCC, whose patients have low survival rates. For purpose, researched molecular structures and protein interactions involved in the initiation HCC. We exploited microarray data samples their gene expression profiles from literature. During analysis, implemented statistical analysis technique...

Congenital microcephaly is the clinical presentation of significantly reduced head circumference at birth. It manifests as both non-syndromic—microcephaly primary hereditary (MCPH)—and syndromic forms and shows considerable inter- intrafamilial variability. has been hypothesized that additional genetic variants may be responsible for this variability, but data are sparse. We have conducted deep...

Background:!!Children!!with!ependymoma!may!experience!a!relapse!!in!up!to!50%!of!cases!depending!!on!the!extent!!of!resection.!Key!biological!events!associated!with!recurrence!are!unknown.!Methodology/Principal!!Findings:!!To!!discover!!the!!biology!!behind!!the!!recurrence!!of!!ependymomas,!!we!!performed!CGHarray!!and!!a!!dual-color!!gene!!expression!!microarray!!analysis!!of!!17!...

Conflicts in recommended medical interventions regularly arise when multiple treatments are simultaneously needed for patients with comorbid diseases. An approach that can automatically repair such inconsistencies and generate conflict-free combined treatments is thus a valuable aid for clinicians. In this paper we propose an answer set programming based method that detects and repairs conflict...