Low-carbohydrate diets, notably the Atkins Diet, were particularly popular in Britain and North America in the late 1990s and early 2000s. On the basis of a discourse analysis of bestselling low-carbohydrate diet books, I examine and critique genetic and evolutionary explanations for obesity and diabetes as they feature in the low-carbohydrate literature. Low-carbohydrate diet books present two...

OBJECTIVE To investigate the effect of commercial weight loss programmes on macronutrient composition and micronutrient adequacy over a 2 month period. DESIGN Adults were randomly allocated to follow the Slim Fast Plan, Weight Watchers Pure Points Programme, Dr Atkins' New Diet Revolution, or Rosemary Conley's "Eat Yourself Slim" Diet & Fitness Plan. SETTING A multi-centre randomised contro...

As ketogenic diets become more frequently used as a standard treatment for epilepsy in children and adults, hospital and community neurologists, pediatricians, intensivists, general practitioners, and house officers will readily encounter patients who are receiving these dietary treatments. A growing body of evidence demonstrates that dietary therapies for epilepsy (classic ketogenic diet, medi...

PURPOSE To determine the efficacy of the Modified Atkins Diet (MAD) and Ketogenic Diet (KD) in seizure control within a population of myoclonic-astatic epilepsy (MAE) patients. METHODS This was a retrospective, single center study evaluating the seizure control by high fat diets. Seizure diaries kept by the parents performed seizure counts. All patients met the clinical criteria for MAE. RE...

Mitochondrial myopathy (MM) with progressive external ophthalmoplegia (PEO) is a common manifestation of mitochondrial disease in adulthood, for which there is no curative therapy. In mice with MM, ketogenic diet significantly delayed progression of the disease. We asked in this pilot study what effects high-fat, low-carbohydrate "modified Atkins" diet (mAD) had for PEO/MM patients and control ...

1. Yang Y, Wu J, Liu H, Chen X, Wang Y, Zhao M, et al. Two homozygous nonsense mutations of GNPTAB gene in two Chinese families with mucolipidosis II alpha/beta using targeted next‐generation sequencing. Genomics 2013;102:169‐73. 2. Aynaci FM, Cakir E, Aynaci O. A case of I‐cell disease (mucolipidosis II) presenting with craniosynostosis. Childs Nerv Syst 2002;18:707‐11. 3. Donald F, Farrell. M...

This paper intends to describe the conceptual design of a Cable Stayed Bridge at Taunton, Somerset, United Kingdom. The development of the detailed design and the critical issues associated with the aerodynamic effects, fatigue effect on cable stays, layout of cable stays, deck and pylon of the cable stayed bridge have been briefly discussed. The design aimed to meet the Client’s requirement of...

A total of 39 Vibrio cholerae non O1 non O139 strains were isolated from surface waters of different parts of Dhaka City, Bangladesh. All these strains showed lack of ctx or zot gene, as demonstrated by the PCR analysis. Eighteen representative strains were tested for enterotoxin production using a rabbit ileal loop model, of which live cells of 8 strains and culture filtrates of 6 strains prod...

I thank Susan Ashford, Connie Gersick, Jane Dutton, Robin Ely, Jack Gabarro, Martin Gargiulo, Linda Johanson, Keith Murnighan, Anat Rafaeli, Ed Schein, Robert Sutton, Richard Walton, Karl Weick, and my anonymous reviewers for their helpful comments on earlier versions, and Nicole Sackley, Jennifer Suesse, and Naomi Atkins for their research assistance. The Harvard Business School Division of Re...

BACKGROUND In the progression of acne vulgaris, the disruption of follicular epithelia by an over-growth of Propionibacterium acnes (P. acnes) permits the bacteria to spread and become in contact with various skin and immune cells. METHODOLOGY/PRINCIPAL FINDINGS We have demonstrated in the present study that the Christie, Atkins, Munch-Peterson (CAMP) factor of P. acnes is a secretory protein...