in this study we investigated histopathological changes of mice ovarian tissues following long-term administration of copper sulfate and induction of chronic copper poisoning. the study comprised of three different groups of twenty one mice as follows: the first group (group 100) which treated by gavage with copper sulfate at a dose of 100 mg kg-1 for 5 weeks. the second group (group 200), whic...

background: imatinib mesylate, a small-molecular analog of adenosine triphosphate (atp) that potently inhibits tyrosine kinase activities of bcr–abl, pdgfr-β, pdgfr-α, c-fms, arg and c-kit, is one of the novel molecularly targeted drugs being introduced into cancer therapy. we tested the effect of imatinib on the ovarian histological structure and the concentration of estrogen and progesterone,...

background: nowadays it is proofed that the uterine artery plays essential role in follicular growth and/or post parturition hemorrhagic. objective: this study was conducted to evaluate the effect of bilateral uterine artery ligation (bual) on follicular fate and the probable histochemical changes of the carbohydrate and lipids in the ovaries of rabbits. materials and methods: 24 mature female ...

There is accumulating evidence that local renin-angiotensin systems (RASs) influence cell growth and organ function in a variety of tissues including the ovary. The first aim of this study was to characterise the cellular location of RAS components in the rat ovary. This was facilitated by the use of the hypertensive transgenic (mRen-2)27 rat which overexpresses renin and angiotensin in extra-r...

An attempt was made to describe the updated information about the factors to be concerned before using of buffalo follicular fluid for supplementation in vitro of buffalo oocyte. There are not only diameter of the follicle, the present of corpus luteum (CL), growth of follicles, stage of estrus cycle, healthy and atretic state of the ovarian follicles. The progesterone and estradiol-17B concent...

High-producing dairy cows are subfertile; however, the mechanisms responsible for the decreased fertility are unknown. The aim of the present study was to test the hypothesis that culled dairy cows (4-8 years old) characterised by 'Lo' ovaries (i.e. those with <10 mid-antral follicles) are affected by premature ovarian senescence. Cows in which both ovaries were 'Lo' ovaries represented 5% of t...

BACKGROUND Nicotine exposure causes impaired fertility and ovarian dysfunction. The aim of this study was to investigate the possible protective role of melatonin, which is known as an antioxidant agent on altered ovarian functions upon nicotine exposure. METHODS A total of 32 female adult NMRI mice were divided randomly into four groups (n = 8). The control group received vehicle, while grou...

OBJECTIVE To localize (by the light and electron microscopy) and partially characterize the antigen recognized by the Mab4E6 in rat ovaries. METHODS Monoclonal antibody (4E6) against a rat ovarian granulosa cell antigen was prepared and identified the 40kDa protein specific for rat steroid producing cells. The localization of this antigen was studied by light and electron microscopic immunocy...

Angiogenesis and vascular regression are critical for the female ovulatory cycle. They enable progression and regression of follicular development, and corpora lutea formation and regression. Angiogenesis in the ovary occurs under the control of the vascular endothelial growth factor-A (VEGFA) family of proteins, which are generated as both pro-(VEGF(165)) and anti(VEGF(165)b)-angiogenic isofor...

Studies of selenium (Se) status indicate that Se is necessary for fertility but how precisely is not known. We aimed to show that Se was important in bovine female reproductive function. The elemental distribution in the bovine ovary (n = 45 sections) was identified by X-ray fluorescence (XRF) imaging. Se was consistently localized to the granulosa cell layer of large (>10 mm) healthy follicles...