Meningiomas are mostly benign brain tumours, with a potential for becoming atypical or malignant. On the basis of comprehensive genomic, transcriptomic and epigenomic analyses, we compared benign meningiomas to atypical ones. Here, we show that the majority of primary (de novo) atypical meningiomas display loss of NF2, which co-occurs either with genomic instability or recurrent SMARCB1 mutatio...

Background: Atypical hemolytic uremic syndrome (aHUS) is a life-threatening and scarce disorder characterized by acute renal failure and disease, non-immune microangiopathic hemolytic anemia and thrombocytopenia, leading to end-stage renal failure or death, and consequently maybe accompanying by extra renal manifestations. Case report: We reported aHUS accompanied by autoimmune hemolytic anemi...

FDG PET CT scan is considered to be a sensitive tool to detect skeletal metastasis in known malignancies. However, it’s high sensitivity and low specificity may account for false positive diagnosis in cases of trauma, infection, inflammation and other benign conditions. Skeletal hemangioma is one of the common benign conditions which are typically ametabolic on FDG PET CT with no uptake on bone...

BACKGROUND Recently, several new atypical antipsychotic agents have been introduced in Ontario, and regulatory warnings have been issued regarding use of atypical antipsychotics in older adults. We sought to establish the impact of newer atypical antipsychotics on prescribing rates and costs. METHODS We performed a population-based cross-sectional study of Ontario adults aged 65 years or more...

PURPOSE We examined rebiopsies in MUSIC (Michigan Urological Surgery Improvement Collaborative) to understand adherence to guidelines recommending repeat prostate biopsy in patients with multifocal high grade prostatic intraepithelial neoplasia or atypical small acinar proliferation. MATERIALS AND METHODS We analyzed data on men undergoing repeat biopsy, practice patterns and cancer detection...

Objective. Arguing that additional symptoms should be added to the criteria for atypical depression. Method. Published research articles on atypical depression are reviewed. Results. (1) The original studies upon which the criteria for atypical depression were based cited fatigue, insomnia, pain, and loss of weight as characteristic symptoms. (2) Several studies of DSM depressive criteria found...

The goal of this paper is to derive in the two-dimensional case necessary and sufficient minimality conditions in terms of the second variation for the functional v 7→ ∫ Ω ( |∇v| + χ{v>0}Q ) dx, introduced in a classical paper of Alt and Caffarelli. For a special choice of Q this includes water waves. The second variation is obtained by computing the second derivative of the functional along su...

JNeurosci will be joining its sibling eNeuro on a new online platform that will allow several innovations to its format. This has been a massive undertaking, and everything possible has been done to make sure the transition is a smooth one. This preparation is almost complete, and the new platform will go live in October. For our authors and reviewers, the migration will be seamless since there...