Tuberculous meningitis and meningoencephalitis are rare and dangerous complications of infections with mycobacteria-complex. Usually these are complications of systemic florid infection with Mycobacterium (M.) tuberculosis. They are most often seen in immune compromised patients. The confirmation of diagnosis can be elaborate and delayed due to long-term culture requirements for M. tuberculosis...

A n 80-year-old white male diagnosed with de novo B-cell prolymphocytic leukemia (B-PLL) presented with increasing fatigue and moderate splenomegaly without palpable lymphadenopathy following treatment with chlorambucil. A chest CT scan showed pulmonary infiltrates, presumed to be leukemic, with a nondiagnostic bronchoalveolar lavage. The white blood cell (WBC) count was 72 3 10/L, with 82% pro...

Tests for antibodies to Epstein-Barr viral capsid antigen or Epstein-Barr nuclear antigen are the most sensitive, are highly specific, and are also the most expensive for diagnosing infectious mononucleosis (strength of recommendation [SOR]: C, based on validating cohort study). Heterophile antibody tests have similar specificity and are cheaper, but are less sensitive in children or in adults ...

We report a case of granulomatous slack skin, a rare and indolent subtype of mycosis fungoides. It affects mainly men between the third and fourth decades. It is characterized by hardened and erithematous plaques that mainly affect flexural areas and become pedunculated after some years. Histological examination shows a dense infiltrate of small atypical lymphocytes involving the dermis (and so...

Splenic lymphoma with villous lymphocytes is a new entity characterised by the presence of atypical lymphocytes in the peripheral blood and bone marrow, and splenic infiltration in the white and red pulp. Cell membrane markers are those of a B mature cell, and no particular chromosomal abnormalities have been associated with this disease. A case of this rare lymphoma occurred in two sisters. Hi...

ETHAL MIDLINE granuloma and lymphomatoid L granulomatosis are related angiocentric, angiodestructive lymphoproliferative disorders that involve the upper and lower respiratory tracts, respectively. They are both characterized by a heterogeneous infiltrate composed of small lymphocytes, mononuclear phagocytes, plasma cells, occasional eosinophils, and variable numbers of large, atypical lymphoid...

Etoposide (ETP) is a topoisomerase Ⅱ (TOP Ⅱ) inhibitor and one of the leading chemotherapeutic drugs for treating wide variety tumors. However, ETP induced hepatotoxicity nephrotoxicity limits its clinical use. This study aims to investigate protective potential taurine (Tau) mitigated histopathological changes in liver kidneys female albino rats treated with ETP. A total 18 were divided into t...

Introduction: Dengue fever is the most common cause of arboviral disease. presents with confusing clinical profile and dengue diagnosed by reverse transcription polymerase chain reaction. Hematological parameters like platelet count, hematocrit, leucocyte count peripheral smear findings will aid in diagnosis whereas malaria which responsible for Leukemia, anemia thrombocytopenia. Method: Total ...

A70-year-old man presented with dyspnea and thoracic pain. A chest X-ray was taken and a spontaneous pneumothorax was diagnosed; however, hematologic values were: Hb 9 g/dL; WBC 20310/L with 18% neutrophils, 71% lymphocytes, and 1% monocytes; platelets 1,1003 10/L. Ultrasonography showed mild splenomegaly (16.7 cm). Circulating lymphocytes were analyzed by flow cytometry and were found to be CD...

Infectious mononucleosis (IM) 1 is a usually benign lymphoproliferative disease caused by Epstein-Barr virus (EBV) (1). Atypical lymphocytosis, the major hematologic abnormality of the disease, is due largely but not exclusively to the proliferation of immunologically activated T lymphocytes which are presumably reactive against EBV-infected lymphocytes (2, 3). Since EBV transforms resting huma...