We have developed an iterative approach based on Independent Component Analysis (ICA) to obtain improved estimates of auditory evoked potentials (AEPs), which represent the electrical response of the brain to auditory stimuli. AEPs are often contaminated by artifacts which reduce the localization accuracy of the sources underlying the surface recordings. We use ICA to separate the activity of n...

The effects of 10%, 30% and 50% nitrous oxide on visual, auditory and somatosensory evoked potentials were studied in seven healthy volunteers. The evoked potentials were averaged from the electroencephalogram following repeated peripheral sensory stimulation of the appropriate modality. Latencies and amplitudes of the resulting potentials were measured and compared with control values. In five...

This study investigated the tonotopic organization of pure-tone-evoked middle latency auditory evoked potentials (MAEPs) recorded at the auditory cortical surface in unanesthetized gerbils. Multielectrode array recording and multiple linear regression analysis of the MAEP demonstrated different degrees of tonotopic organization of early and late MAEP components. The early MAEP components P1 and...

The precedence effect in subjective localization tasks reflects the dominance of directional information of a direct sound (lead) over the information provided by one or several reflections (lags) for short delays. By collecting data of both psychoacoustical measurements and auditory evoked potentials the current study aims at neurophysiological correlates for the precedence effect in humans. I...

Mercury is known to alter neuronal function and has been shown to cross the placental barrier. These experiments were undertaken to examine if gestational exposure to mercury vapor (Hg(0)) would result in alterations in sensory neuronal function in adult offspring. Dams were exposed to 0 or 4 mg/m(3) Hg(0) for 2 h/day from gestational days 6-15. This exposure paradigm has been shown to approxim...

The aim of our research was to estimate the time course of development and plasticity of the human central auditory pathways following cochlear implantation. We recorded cortical auditory-evoked potentials in 3-year-old congenitally deaf children after they were fitted with cochlear implants. Immediately after implantation cortical response latencies resembled those of normal-hearing newborns. ...

The mammalian auditory cortex integrates spectral and temporal acoustic features to support the perception of complex sounds, including conspecific vocalizations. Here we investigate coding of vocal stimuli in different subfields in macaque auditory cortex. We simultaneously measured auditory evoked potentials over a large swath of primary and higher order auditory cortex along the supratempora...

P2 and N1c components of the auditory evoked potential (AEP) have been shown to be sensitive to remodeling of the auditory cortex by training at pitch discrimination in nonmusician subjects. Here, we investigated whether these neuroplastic components of the AEP are enhanced in musicians in accordance with their musical training histories. Highly skilled violinists and pianists and nonmusician c...