نتایج جستجو برای: auto immune disease
تعداد نتایج: 1710635 فیلتر نتایج به سال:
Myocarditis, often triggered by viral infection, may lead to heart auto-immunity and dilated cardiomyopathy. What determines the switch between disease resolution and progression is however incompletely understood. We show that pharmacological inhibition of STAT3, the main mediator of IL-6 signalling and of Th17-cell differentiation, protects mice from the development of Experimental Auto-immun...
Rituximab, a monoclonal antibody directed against the CD20 antigen, found on certain B-cell subsets, results in significant B-cell depletion and has been increasingly used in immune-mediated renal disease and transplantation. Although originally applied to what were considered antibody-mediated diseases, it has become clear that auto- and alloreactive B cells contribute in many ways to immune d...
Myelin oligodendrocyte glycoprotein (MOG) is an antigen of the myelin sheath, which may trigger immune cell responses and the production of auto-antibodies in multiple sclerosis (MS). In this study, we used MOG(35-55) -induced experimental autoimmune encephalomyelitis (EAE), a model of human MS, to assess the production of catalytically active immunoglobulin G (IgG) antibodies or abzymes which ...
The network theory of the immune system proposes that idiotype-anti-idiotype interactions provide important immunoregulatory controls (1). In many experimental systems, the passive administration of heterologous anti-idiotypic ant ibody has been shown to enhance (2) or suppress (3) immune responses. In addition, spontaneous auto-anti-idiotypic antibody has been detected after antigenic challeng...
A uto-immune diseases are a major health problem in both developed and developing countries: They cause as many deaths as the leading infectious diseases and exact an even greater toll on patients’ quality of life given their chronic nature (Box 1). Reliable data for all auto-immune diseases are hard to collect, but a 2011 study by the American Autoimmune Related Diseases Association (AARDA) re...
Stress-induced cardiomyopathy, in contrast to acute myocardial infarction, is a type of heart failure characterized by reversible left ventricular dysfunction. Cardiac imaging primarily reveals ventricle stunning, 81.7% which apical type. Emotional or psychological stress usually precedes the onset stress-induced increasingly being recognized as unique neurogenic stunning disease. To distinguis...
Professor da Disciplina de Neurologia e Neurocirurgia do Curso de Medicina da Universidade Estadual do Oeste do Paraná UNIOESTE, Paraná, Brasil; Professor da Disciplina de Clínica Cirúrgica do Curso de Medicina da Universidade Estadual do Oeste do Paraná UNIOESTE, Paraná, Brasil; Chefe do Serviço de Coloproctologia do Hospital Universitário Cajuru PUCPR, Paraná, Brasil. Infliximab, eternecept a...
The central role of protein kinases in controlling disease processes has spurred efforts to develop pharmaceutical regulators of their activity. A rational strategy to achieve this end is to determine intrinsic auto-regulatory processes, then selectively target these different states of kinases to repress their activation. Here we investigate auto-regulation of the innate immune effector protei...
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