objectives the aim of this study was to investigate the effects of local cryotherapy on the intensity of chemotherapy-induced oral mucositis in autologous bone marrow transplantation patients. patients and methods in this single, blinded, randomized clinical trial, 29 patients undergoing stem cell transplantation in iran were selected by convenience sampling, and randomly allocated to control (...

5th Would Conference on Lung Cancer 6 Banham F, Soukop M, Burnett A, et al. Treatment of small cell carcinoma of lung with a late dosage intensification programme containing cyclophosphamide and mesna. Cancer Treat Rep 1983; 10:(suppl):73-77 7 Sculier JP, Klastersky J, Stryckmans P, et al. Late intensification in small cell lung cancer: a phase 1 study of high dose of cycbophosphamide and etopo...

T101-ricin A-chain immunotoxin is a hybrid molecule made up of the T101 monoclonal antibody bound to the A-chain of ricin. It specifically destroys cells expressing the cell surface T65 antigen. We have designed a preclinical study to evaluate its possible use for the in vitro treatment of T-cell hematological cancers prior to autologous bone marrow transplantation. The data presented here show...

Over the past decade, relevant improvements and refinements have significantly changed the indications, technique and results obtained with allogeneic transplantation of hematopoietic stem cells (HSC) in childhood. In this review the most important innovations that have characterized the practice of HSC transplantation in childhood during this decade will be discussed. We will analyze the clini...

Levitt et aP and Greenberg et al’ have recently described elegant immunologic methodologies for selectively isolating T lymphocytes’ or hematopoietic progenitor cells2 from small aliquots of human marrow. In both cases the initial marrow manipulation, following aspiration, involved selective isolation of light-density mononuclear cells using Ficoll-Hypaque (I .077 ± 0.003 g/dL) gradients. Poten...

Evidence supporting the role of hematopoietic stem cell transplantation (SCT) in the therapy of multiple myeloma (MM) is presented and critically evaluated in this systematic evidence-based review. Specific criteria were used for searching the published medical literature and for grading the quality of the evidence, the strength of the evidence, and the strength of the treatment recommendations...

Increasingly, allogeneic and even more often autologous bone marrow transplants are being done to correct a wide variety of diseases. In addition, autologous marrow transplants potentially provide an opportune means of delivering genes in transfected, engrafting stem cells. However, despite its widespread clinical use and promising gene therapy applications, relatively little is known about the...

The prevalence of end-stage heart failure is rising despite presence successful reperfusion strategies for treating acute myocardial infarction and advancements made in pharmacological device therapy optimized management. non-availability a mature cardiac transplantation programme absence left right ventricular assist devices many parts the world has renewed interests potential alternative opti...

There is currently great interest in the use of mesenchymal stem cells as a therapy for multiple sclerosis with potential to both ameliorate inflammatory processes as well as improve regeneration and repair. Although most clinical studies have used autologous bone marrow-derived mesenchymal stem cells, other sources such as allogeneic umbilical cord-derived cells may provide a more accessible a...

Alkyl-lysophospholipids (ALP) are analogues of 2-lysophosphatidylcholine that have been reported to have selective antitumor activity. These compounds could potentially be useful in purging bone marrow of leukemic cells in autologous marrow transplantation in acute leukemia. To determine the efficacy of pharmacological purging by ALP, we have designed a human assay system to mimic the condition...