Since Hodgkin and Huxley discovered the potassium current that underlies the falling phase of action potentials in the squid giant axon, the diversity of voltage-gated potassium (Kv) channels has been manifested in multiple ways. The large and extended potassium channel family is evolutionarily conserved molecularly and functionally. Alternative splicing and RNA editing of Kv channel genes dive...

The problem of data sparsity largely limits the accuracy of recommender systems in collaborative filtering model. To alleviate the problem, cross-domain collaborative filtering was proposed by harnessing the information from the auxiliary domains. Previous works mainly focused on improving the model of utilizing the auxiliary information yet little on the selection of auxiliary domains, althoug...

We prove uniqueness and existence theorems for four-dimensional asymptotically flat, Ricci-flat, gravitational instantons with a torus symmetry. In particular, we that such are uniquely characterised by their rod structure, which is data encode the fixed point sets of action. Furthermore, establish every admissible structure there exists an instanton smooth up to possible conical singularities ...

Simulating charged many-body systems has been a computational demanding task due to the long-range nature of electrostatic interaction. For multi-scale model electrolytes which combines strengths atomistic/continuum electrolyte representations, harmonic surface mapping algorithm is developed for fast and accurate evaluation reaction potentials. Our method reformulates potential into sum image c...

BACKGROUND Mutations in the gene encoding the human cardiac Na(+) channel alpha-subunit (hH1) are responsible for chromosome 3-linked congenital long-QT syndrome (LQT3) and idiopathic ventricular fibrillation (IVF). An auxiliary beta(1)-subunit, widely expressed in excitable tissues, shifts the voltage dependence of steady-state inactivation toward more negative potentials and restores normal g...

In deep learning, auxiliary modules for model training have become increasingly popular, such as Deep Mutual Learning (DML) and Multi-Scale Dense Convolutional Networks (MSDNet), which can maximize the performance of without increasing amount test computation. Nevertheless, current research does not fully exploit knowledge between different modules. This paper proposes a new technique–Siamese L...

introduction: considering the antiepileptogenic effects of repeated transcranial magnetic stimulation (rtms), the effect of rtms applied during amygdala kindling on spontaneous activity of hippocampal ca1 pyramidal neurons was investigated. materials and methods: a tripolar electrode was inserted in basolateral amygdala of male wistar rats. after a recovery period, animals received daily kindli...

Auxiliary selection is paradoxical: categorical for some verb classes, indeterminate for others; inconsistent across languages; and misaligned with other diagnostics. After critiquing one solution to the paradox, the Auxiliary Selection Hierarchy (Sorace 2000), we propose an alternative: Parameterized Linking, which approaches the semantic underpinnings of the unaccusative/unergative distinctio...