It remains unclear to what extent drugs targeting transcriptional repressor complexes affect global gene expression in cells derived from target and nontarget human tissues. To address this question, we used genome-wide expression analysis using microarrays to analyze the response of three tumor and one normal epithelial cell line to treatment with the DNA methyltransferase inhibitor 5-aza-2'-d...

BACKGROUND Debate exists regarding to whether thiopurine therapy is as effective in ulcerative colitis (UC) as it is in Crohn's disease. AIM To review systematically the efficacy of azathioprine (AZA) and mercaptopurine (MP) in UC, and to conduct a meta-analysis of randomized clinical trials evaluating the efficacy of AZA/MP for the induction or maintenance of UC clinical remission. METHODS...

PURPOSE Oral wound healing requires gingival fibroblasts to respond to local growth factors. Epigenetic silencing through DNA methylation can potentially decrease the responsiveness of gingival fibroblasts to local growth factors. In this study, our aim was to determine whether the inhibition of DNA methylation sensitized gingival fibroblasts to transforming growth factor-β1 (TGF-β1). METHODS...

BACKGROUND Diuretic agents are widely used on the treatment of water retention related diseases, among which acetazolamide (AZA) acts originally as a carbonic anhydrase (CA) inhibitor. Aquaporin-1 (AQP1) being located in renal proximal tubules is required for urine concentration. Previously our lab has reported AZA putatively modulated AQP1. Aim of this study is to testify our hypothesis that r...

Retrospective data was collected from 77 elderly acute myeloid leukemia (AML) patients treated with Azacitidine (AZA) and 50 elderly AML patients treated with intensive chemotherapy (IC) from 4 Portuguese Hospitals. Median OS was 10.6 months in those receiving AZA as 1st line. Response (overall response rate 44%) had a significant impact on overall survival (p=<0.0001). Median OS of the compara...

The study reports the convenient and efficient synthesis of several new analogues of 3β-substituted amides of 17a-aza-Dhomo-4-androsten-17-one (3a-3e) from commercially available Diosgenin as the starting material. The structures of newly synthesized compounds were confirmed by IR, 1H NMR, 13C NMR and Mass spectrometry. We herein report the 5αreductase inhibitory, antimicrobial and antioxidant ...

Background: Therapy of Crohn disease (CD) with anti-tumor necrosis factor biologics and/or immunomodulators has altered the disease natural history. The comparative efficacy and safety of these medications alone or in combination is unknown. Objective: To evaluate the efficacy and safety of infliximab (IFX) monotherapy, azathioprine (AZA) monotherapy, and combination therapy in patients with mo...

Significance: This paper describes the palladiumcatalyzed enantioselective aza-Morita–Baylis–Hillman reaction of acrylonitriles with imines. The bulky pincer ligand enabled the synthesis of enantioenriched α-methylene-β-aminonitriles in high yield. Comment: The palladium–pincer complex preferably activates acrylonitrile, even in the presence of ethyl acrylate. The palladium ketenimide is a key ...

A commercially available neem seed extract, Neemix 4.5, containing 4.5% azadirachtin (AZA), was assessed for biological activity against the root weevil Diaprepes abbreviatus (L.), an important exotic insect pest of Florida citrus. Laboratory bioassays against neonatal and 3-wk-old larvae fed sliced carrot treated with Neemix produced dose-dependent larval mortality and reduced fresh weights am...

BACKGROUND Thiopurine S-methyltransferase (TPMT) is an important enzyme in the metabolism of thiopurines including azathioprine (AZA), 6-mercaptopurine, and 6-thioguanine. TPMT genotyping is widely used for screening of AZA-related toxicity during routine clinical practice in Korea. However, the data of TPMT genotypes and its AZA-related toxicity have not been studied in the field of dermatolog...