Immune checkpoint inhibitors (ICIs) are a novel cancer therapy that may induce tumor regression across multiple types of cancer. There has recently been interest in combining the ICIs with other forms treatments, as not all patients benefit from monotherapy. We propose mathematical model consisting ordinary differential equations to investigate combination treatments ICI avelumab and immunostim...

Gap junctional communication between microglia was investigated at rat brain stab wounds and in primary cultures of rat and mouse cells. Under resting conditions, rat microglia (FITC-isolectin-B4-reactive cells) were sparsely distributed in the neocortex, and most (95%) were not immunoreactive for Cx43, a gap junction protein subunit. At brain stab wounds, microglia progressively accumulated ov...

The therapeutic use of ozone has been suggested for a long time in general dentistry and paediatric its antimicrobial, virucidal, disinfectant, biocompatible properties. Ozone also anti-inflammatory, analgesic, immunostimulant properties, it promotes tissue regeneration. Dental treatment children is often complex could support the clinician to enhance approach prognosis with young patients, non...

Caulerpa lentillifera is widely known to have pharmacological benefits based on a variety of research findings. The study aims analyze the potential immunostimulant extract ethanol in blood profiles vivo. methods carried out included extraction ethanol, observation hematological profile erythrocytes, leukocytes and micronucleus phagocytosis activity Balb/c scavengers administered orally with do...