Brownian dynamics simulations of the encounter kinetics between the active site of the wild{type and Glu199 mutant of Torpedo californica acetylcholinesterase (TcAChE) with a charged substrate were performed. In addition, ab-initio quantum chemical calculations using the 3-21G basis set were undertaken to probe the energetics of the transformation of the Michaelis complex into a covalently boun...

Background: Hyperbilirubinemia is one of the most common and persistent problems encountered in preterm newborns. This condition in preterm infant is more likely to be associated with neurological damage rather than terms. So far, no major studies have precisely assessed the effects of zinc sulfate on hyperbilirubinemia in low-birth-weight (LBW) neonates. Therefore, in this study, we aimed to e...