PURPOSE/OBJECTIVES To analyze information about the environments in which the Oncology Nursing Society (ONS) operates as a basis for strategic planning. DATA SOURCES Published reports and ONS internal surveys. DATA SYNTHESIS Analysis of internal and external trends resulted in a list of implications with regard to managing change, avoiding mistakes, and identifying critical issues for ONS l...

OBJECTIVES The aim of this study is to present a case of successful relief of bilateral occipital neuralgia (ON) using unilateral occipital nerve stimulation (ONS) and to discuss the possible underlying mechanisms. MATERIALS AND METHODS We present the case of a 59-year-old female patient with severe bilateral ON treated with unilateral ONS. We systematically reviewed previous studies of ONS f...

Leading edge protrusion of migrating cells involves tightly coordinated changes in the plasma membrane and actin cytoskeleton. It remains unclear whether polymerizing actin filaments push and deform the membrane, or membrane deformation occurs independently and is subsequently stabilized by actin filaments. To address this question, we employed an ability of the membrane-binding I-BAR domain of...

Wavelet Shrinkage de-noi si ng i s appl i ed to El ect rophoret i c Nucl ear Magnet i c Resonance (ENMR) data. Both threshol d rul es for removi ng noi se, namel y sof t and hard, proposed i n Donoho's Vi suShri nk are used simul t aneousl y. Sof t t hreshol di ng i s appl i ed to ne l evel s of wavel et decomposi t i on coe ci ent s and hard threshol di ng to coarse l evel s. Thi s impl ementa...

Syndapin I (PACSIN 1) is a synaptically enriched membrane tubulating protein that plays important roles in activity-dependent bulk endocytosis and neuronal morphogenesis. While syndapin I is an in vitro phosphoprotein, it is not known to be phosphorylated in neurons. Here, we report the identification of two phosphorylation sites, S76 and T181, of syndapin I from nerve terminals. Both residues ...

AIMS Bifunctional apoptosis regulator (BAR) is an endoplasmic reticulum protein that interacts with both the extrinsic and intrinsic apoptosis pathways. We hypothesize that over-expression of BAR Delta RING prevents apoptosis and injury following ischaemia/reperfusion (I/R) and attenuates doxorubicin (DOX)-induced cardiotoxicity. METHODS AND RESULTS We generated a line of transgenic mice that...

In this paper I argue that, far from necessarily hindering bar formation in disc galaxies, inner haloes may stimulate it. This constitutes a new instability mechanism by which bars can grow. To show this I use a number of N-body simulations whose initial conditions have identical discs and more or less concentrated haloes. They show that the bar that grows in the more halo-dominated environment...

Under-nutrition, inadequate protein or poor protein and energy intake and unintended weight loss have been identified as independent risk factors for the development of pressure ulcers. Providing oral nutritional supplements (ONS) in addition to regular food intake seems a logical way to replenish body shortages of macro- and micronutrients as well as to supply extra nutrients for the preservat...