PURPOSE Pterygia are a proliferative and inflammatory growth of limbal epithelial stem cell origin, characterized by corneal tissue invasion and extensive matrix remodeling including the destruction of Bowman's layer (BL). The purpose of this study was to determine the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) at the advancing pterygium edge. METHODS...

The distribution of a range of integrins, E-cadherin, and carcino-embryonic antigen (CEA) like molecules in normal human oesophageal epithelium was investigated immunohistochemically on frozen sections of endoscopic biopsy specimens. The integrin subunits alpha 2, alpha 3, alpha 6, alpha v, beta 1, and beta 5 were expressed throughout the epithelium. There was strong expression of alpha 2, alph...

Basal lamina (BL) is a crucial mechanical and functional component of blood vessels, constituting a sensor of extracellular microenvironment for endothelial cells and pericytes. Recently, an abnormality in the process of matrix microfibrillar component remodeling has been advocated as a mechanism involved in the development of aortic dilation. We focused our attention on BL composition and orga...

Kilohertz-scale quasi-periodic oscillations (kHz QPOs) are a distinct feature of the variability neutron star low-mass X-ray binaries. Among all modes, they especially interesting as probe for innermost parts accretion flow, including boundary layer (BL) on surface star. All existing models kHz QPOs explain only part their rich phenomenology. Here, we show that some properties can be explained ...

We investigate the error scaling and computational cost of wall-modeled large-eddy simulation (WMLES) for external aerodynamic applications. The NASA Juncture Flow is used as representative an aircraft with trailing-edge smooth-body separation. Two gridding strategies are examined: 1) constant-size grid, in which near-wall grid size has a constant value 2) boundary-layer-conforming (BL-conformi...

Wave-induced boundary layer (BL) flows over sandy rippled bottoms are studied using a numerical model that applies a one-way coupling of a “far-field” inviscid flow model to a “near-field” large eddy simulation (LES) Navier– Stokes (NS) model. The incident inviscid velocity and pressure fields force the LES, in which near-field, wave-induced, turbulent bottom BL flows are simulated. A sediment ...

Epidermal stratification of the mammalian skin requires proliferative basal progenitors to generate intermediate cells that separate from the basal layer and are replaced by post-mitotic cells. Although Wnt signaling has been implicated in this developmental process, the mechanism underlying Wnt-mediated regulation of basal progenitors remains elusive. Here we show that Wnt secreted from prolif...

Tomato flower abscises at the anatomically distinct abscission zone that separates the pedicel into basal and apical portions. During abscission, cell separation occurs only at the abscission zone indicating distinctive molecular regulation in its cells. We conducted a transcriptome analysis of tomato pedicel tissues during ethylene promoted abscission. We found that the abscission zone was the...