BACKGROUND A 1995 meta analysis of chemotherapy in patients with advanced non-small cell carcinoma indicated clinical benefit from cisplatin based chemotherapy. Subsequent studies have aimed to increase the efficacy or decrease the toxicity of chemotherapy. PATIENT AND METHODS Illustrative studies and meta analyses of different aspects of chemotherapy which have taken place over the last deca...

The aim was to compare the two most commonly recommended chemotherapy regimens (platinum-based chemotherapy and platinum-taxane combination) with non-platinum-based chemotherapy and those with no chemotherapy in a large nationwide and population-based cohort of patients with ovarian cancer with up to 17 years of follow-up. We studied 12,181 patients diagnosed with stages I-IV ovarian cancer at ...

As a crucial cell cycle regulator and G2/M phase promotor, CCNB1 played an essential role in progression of chemotherapy related cell death. Platinum-based chemotherapy is still the first-line chemotherapy regimen for most advanced NSCLC patients. We aim to investigate the correlation of CCNB1 polymorphisms to the efficiency of platinum-based chemotherapy in Chinese advanced NSCLC patients. We ...

OBJECTIVES The aim of this study was to compare the survival benefits associated with gemcitabine chemotherapy and 5-fluorouracil (5-FU)-based concurrent chemoradiotherapy (CCRT) in locally advanced unresectable pancreatic cancer. METHODS One hundred and thirty-eight locally advanced unresectable pancreatic cancer patients were retrospectively enrolled from January 1995 to January 2005. All c...

introduction: mortality rate of breast cancer has been fallen in recent years. combination of cyclophosphamide, methotrexate, and 5-fluorouracil(cmf), as a pioneer of adjuvant chemotherapy of breast cancer, and later introduced anthracycline/taxane(a/t)-based regimens have both produced favorable outcomes in early-stage breast cancer. the current study, aimed to evaluate the probably different ...

introduction: cyclophosphamide (cp) is used for the treatment of various cancers. in spite of its therapeutic importance, a wide range of adverse effects such as reproductive toxicity has been observed following the administration of this drug in human and experimental animals. in the current study, we have investigated the adverse effects of cp on morphology and histology of testis rats. metho...

background: nausea and vomiting are the most common and unpleasant side effects of chemotherapy, and they may prevent successful treatment completion. antiemetics not only cannot control nausea and vomiting completely but also have numerous side effects. so it is necessary to find other methods for a better control. this study aimed to assess the effect of massage therapy on chemotherapy-induce...

tumor size seems to be a determinant in the prognosis of early cervical cancer. patients with tumor size greater than 4 cm (bulky) in diameter have worse outcome.' the purpose of this study was to compare the efficacy of preoperative combined chemoradiation and neoadjuvant chemotherapy (narc) programs followed by radical hysterectomy in stage ib - lib bulky cervical cancer. from september ...

background: full blood count has been shown to predict disease severity and mortality risk in cancer patients. this study aimed to highlight the degree of derangements of full blood count parameters and provide mean values in pre-chemotherapy breast cancer patients compared with apparently normal control subjects.methods: this was an unmatched case-control study among breast cancer patients att...