Hyoscine-N-butyl bromide is a widely used antispasmodic belonging to the belladonna alkaloid class of semisynthetic quaternary ammonium compounds. These compounds exert a spasmolytic action on the smooth muscles of the bile-gastrointestinal tract, genitourinary tract, salivary glands (xerostomia), and also on the visual apparatus - in particular, the irido-ciliary complex. As a consequence, the...

An efficient protocol for enhancement of total alkaloids production from suspension cultures of A. belladonna L. was established. The effect of MS-medium supplemented with different concentrations of naphthalene acetic acid (NAA) and benzyl adenine (BA) on growth parameters as well as total alkaloid production was investigated. In the same connection, the effect of biotic stress caused by vario...

■ ■ UPC2 method compatible with mass spectrometry for identification of unknown components IN T RODUC T ION The extract of Atropa belladonna, a perennial native to south and central Europe, North Africa, and East Asia has been used for centuries to treat a number of medical conditions, including ulcers and other gastrointestinal disorders, and pain. It is also used as an anti-muscarinic agent. ...