A synthesis of moracin M using Appel dehydration a biomimetic inspired endoperoxide and subsequent late stage aromatization, is described. key 1,3-diene, obtained from base-free Suzuki-Miyaura coupling, can undergo oxidation to its endoperoxide, followed by under conditions aromatization give benzofuran, with deprotection then providing in only 4-steps. Alternatively, this 1,3‑diene synthetic r...

We elaborated a convenient one-step approach for the synthesis of previously unknown 2-(5-acetyl-7-methoxy-2-(4-methoxyphenyl)benzofuran-3-yl)acetic acid. The suggested protocol includes multicomponent reaction acetovanillone, 4-methoxyphenylglyoxal and Meldrum’s have demonstrated that considered is one-pot telescoped process including preliminary condensation components in MeCN followed by aci...