New ytterbium (III) compounds with β-diketones (2,7-dimethyl-octene-1-dione-3,5 and 2,6-dimethylheptene-1-dione-3,5) their derivatives phenanthroline have been synthesized. The composition chemical structure of the obtained complexes determined by several Phy­sico-chemical investigations. It has shown, that Yb ion coordinates three ligand molecules coordination sphere is supplemented two mole­c...

A new butenolide derivative (1), along with three known compounds (2-4) were isolated from the MeOH extract of brown alga Sargassum micracanthum. The structures 1 to 4 determined by analyses 1D and 2D NMR mass spectroscopic data. identified as (5 E,10 Z)-6,10,14-trimethylpentadeca-5,10-dien-2,12-dione (2), E,9 E)-6,10,14-trimethylpentadeca-5,9-dien-2,12-dione (3), (-)-loliolide (4) comparing th...

DNA intercalators belong to aromatic heterocyclic compounds interacting reversibly with DNA. These compounds have been used extremely as cytotoxic agents against cancer. In this study, the synthesis and biological activity of some novel derivatives of cyclopenta [b] quinoline-1, 8-dione as new intercalating agent were investigated. Twenty novel derivatives of cyclopenta [b] quinoline-1, 8-dione...

researchers within the last few decades because of its great potential utility for rapid drug delivery. It offers an attractive alternative for drugs that have limited oral bioavailability, are destroyed by gastrointestinal (GI) fluid, or are highly susceptible to hepatic first pass or gut-wall metabolism. Nasal drug delivery also offers the convenience and safety of noninvasiveness. In additio...

Ethambutol (EMB), the first line drug in the treatment of tuberculosis, is an inhibitor of the biosynthesis of the cell wall compound - arabinogalactan. It was found that EMB at sub-inhibitory concentration increases the permeability of the M. vaccae cell wall, which was monitored by cell sensitization to erythromycin and rifampicin. The high permeability of the cell wall to hydrophobic compoun...

Keloids are benign fibroproliferative tumors with features of raised scar tissue and excessive growth beyond the original border. Keloid scars show extracellular matrix(ECM) deposition rich vasculature. Recently, many studies have revealed important pathways keloid pathogenesis. Herein, we focus on difference between traumatic nontraumatic keloids in a transcriptomic level. To preclude intra-le...

INTRODUCTION ............................................................................................... 609 I. BACKGROUND ..................................................................................... 611 A. Organ Transplantation in the United States ................................ 611 B. The HOPE Act ............................................................................. 615...

In a previous work (Callegari and Yokoyama 2007, Celestial Mechanics and Dynamical Astronomy vol. 98), the main features of the motion of the pair Enceladus-Dione were analyzed in the frozen regime, i.e., without considering the tidal evolution. Here, the results of lots of numerical simulations of a pair of satellites similar to Enceladus and Dione crossing the 2:1 mean-motion resonance are sh...

The dichloromethane extract prepared from the underground parts of Eleutherine bulbosa (Miller) Urban (Iridaceae) showed strong activity in the direct bioautography assay with the phytopathogenic fungus Cladosporium sphaerospermum. This assay was used to guide the fractionation of this extract and allowed the isolation of four compounds: the new naphthoquinone eleutherinone[8-methoxy-1-methyl-1...

Electronic absorption spectra of chrysophanol (1,8-dihydroxy-3-methylanthracene-9,10-dione), physcion (1,8-dihydroxy-3-methoxy-6-methylanthracene-9,10-dione) and emodin (1,3,8trihydroxy-6-methylanthracene-9,10-dione) were investigated. Molecular geometries of the substituted anthraquinones in the ground state were optimized using semiempirical AM1 method without imposing any symmetry constrains...