There is well documented relationship between dermatoglyphics and specific syndromes of genetic origins. Since beta-thalassemia is a major genetic disorder in West Bengal, India, therefore, rapid diagnosis of major beta thalassemia along with certain preventive measures is of utmost significance. The aim of the present study was to understand the association of the finger prints patterns among ...

background: one of the most common endocrine problems in major beta-thalassemia is hypothyroidism (ht). the aim of this study was to evaluate thyroid function status in major beta-thalassemia patients older than 10 years old. methods: this cross sectional study was carried out on thalassemia major patients registered on thalassemia center of amirkola children hospital in babol. a questionnaire ...

background: thalassemia represents a serious health problem in iran because of its heterogeneous frequency and the existing endogamy system. it is an inherited blood disease characterized by the under production of normal hemoglobin, the oxygen-carrying protein in red blood cells. materials and methods: in this study, serum antioxidants including selenium (se), zinc (zn) and copper (cu) were me...

In recent years there have been major advances in our knowledge of the regulation of iron metabolism that have had implications for understanding the pathophysiology of some human disorders like beta-thalassemia and other iron overload diseases. However, little is known about the relationship among ineffective erythropoiesis, the role of iron-regulatory genes, and tissue iron distribution in be...

One of the genetic features of the Sardinian population is the high prevalence of hemoglobin disorders. It has been estimated that 13% to 33% of Sardinians carry a mutant allele of the alpha-globin gene (alpha-thalassemia trait) and that 6% to 17% are beta-thalassemia carriers. In this population, a single mutation of beta-globin gene (Q39X, beta(0) 39) accounts for >95% of beta-thalassemia cas...

background: beta-thalassemia major is a severe and lethal hemolytic anemia. regular transfusion is necessary for avoidance of its complications but it may end to cardiac involvement secondary to iron overload. angiotensin converting enzyme inhibitors (aceis) are useful medications even in early stages of heart failure. we studied the effects of two common aceis on improvement of heart function ...

introduction and objective: zinc as the second trace element of the human body plays an important role in numerous functions. a large number of research studies have showed serum zinc deficiency and excess urinary excretion in patients with major beta thalassemia, but few studies revealed excess urinary zinc excretion in minor beta thalassemia and no study investigated serum zinc levels in this...

introduction: in  major b -thalassemia impaired biosynthesis of beta hemoglobin leads to accumulation of unpaired alpha hemoglobin chain. an iron overload generates oxygen-free radicals which ultimately leads to tissue injury. the aim of this investigation was to evaluate serum antioxidants in patients with major b -thalassemia and those with minor thalassemia in comparison with respective age ...

disturbances in calcium metabolism and both impairment are some of the known complications observed in beta thalassemia major patients.although iron deposition has been recognized to be the main factor for organ dysfunction in these patients,the relatively low prevalence of hypoparathyroidism has led to giving more emphasis to Ca metabolism disturbance among others.availability of more patients...