The skin barrier, located in the stratum corneum, is influenced mainly by the lipid and protein composition of this layer. In eczematous diseases impairment of the skin barrier is thought to be of prime importance. Topical anti-inflammatory drugs and emollients are the most widely used eczema treatments. The aim of this study was to examine the effects of topically applied corticosteroid, tacro...

BACKGROUND Parthenium hysterophorus is the commonest cause of airborne contact dermatitis in India. Azathioprine has been shown to be effective and safe in parthenium dermatitis, but there are no reports of comparison of steroids and azathioprine in this condition. AIMS To study the therapeutic efficacy of azathioprine versus betamethasone in patients having contact dermatitis to parthenium a...

OBJECTIVES In two separate trials, we studied the concomitant administration of atosiban with labetalol and betamethasone to determine any possibility of a clinically relevant pharmacokinetic interaction. DESIGN Study 1 was an open-label, single dose atosiban, multiple dose labetalol, interaction study. Study 2 was an open-label, randomised, three-period crossover pharmacokinetic study. SET...

Antenatal corticosteroids (ACS) are part of the standard care for women at risk premature birth to reduce adverse neonatal outcome. Neonatal benefits optimized when ACS administered 2-7 days before delivery. Less is known about a shorter administration-to-birth interval less than 48 hours. We assessed association between short Corticosteroid Administration-to-Birth Interval and A retrospective ...

Background: Calcipotriol/betamethasone dipropionate ointment has been successfully used in psoriasis vulgaris of active stage. However, the data of stationary stage was lack. Aims: To investigate the optimal regime of calcipotriol/betamethasone dipropionate ointment on psoriasis vulgaris of stationary stage. Methods: Patients were randomized into 3 groups, with calcipotriol/betamethasone ointme...

BACKGROUND Topical treatments are usually effective in mild psoriasis. However, the complexity of their use may result in low patient adherence with treatment. Combination of a vitamin D analog and a corticosteroid into a two-compound topical formulation has increased efficacy compared with either drug administered alone. Once-daily application of such a product would likely improve adherence. ...

Ten children with severe asthma, who had been well controlled on maintenance betamethasone valerate aerosol for an average of 11 months, were given placebo aerosols without their knowledge. The period of placebo substitution was campared with one 28-day period of betamethasone valerate therapy beforehand, and two 28-day periods afterwards. Symptoms were increased during the placebo period, and ...

BACKGROUND Despite efforts to treat trachyonychia, there is no promising treatment modality. OBJECTIVE This study evaluated the efficacy and safety of calcipotriol plus betamethasone dipropionate ointment on trachyonychia. METHODS A total of 39 patients with 432 nails affected by trachyonychia were enrolled. All patients applied calcipotriol/betamethasone ointment once daily without occlusi...

BACKGROUND Both dexamethasone and betamethasone, given to women at risk of preterm birth, substantially improve short-term neonatal health, increase the chance of the baby being discharged home alive, and reduce childhood neurosensory disability, remaining safe into adulthood. However, it is unclear which corticosteroid is of greater benefit to mother and child.This study aims to determine whet...

OBJECTIVE To examine the effects of three commonly used intra-articular depot corticosteroid preparations tested in a rat air pouch model and their effect against monosodium urate (MSU) crystal-induced inflammation. Rheumatologists use intra-articular corticosteroid preparations to relieve pain and inflammation of acute monoarthritis without really knowing their effects on the synovial fluid an...