The analytic center of an n dimensional polytope P fx R aTi x bi i m g with a nonempty interior Pint is de ned as the unique minimizer of the logarithmic potential function F x Pmi log aTi x bi over Pint It is shown that one cycle of a conjugate direction method applied to the potential function at any v Pint such that q v Tr F v generates a point x Pint such that q x Tr F x pn

The scavenger receptor class B type I (SR-BI) is a multi-ligand receptor that can mediate the binding and bi-directional lipid transfer between high-density lipoproteins (HDLs) and cells. It is expressed in a variety of tissues, including the liver, and in macrophages in atherosclerotic plaques. The physiological role of SR-BI has been tested in vivo by the genetic manipulation of SR-BI levels ...

High density lipoprotein (HDL) represents a mixture of particles containing either apoA-I and apoA-II (LpA-I/A-II) or apoA-I without apoA-II (LpA-I). Differences in the function and metabolism of LpA-I and LpA-I/A-II have been reported, and studies in transgenic mice have suggested that apoA-II is pro-atherogenic in contrast to anti-atherogenic apoA-I. The molecular basis for these observations...

Abstract: Bi-level programming, a tool for modeling decentralized decisions, consists of the objective(s) of the leader at its first level and that is of the follower at the second level. Three level programming results when second level is itself a bi-level programming. By extending this idea it is possible to define multi-level programs with any number of levels. Supply chain planning problem...

This paper presents the Malmö Breast Tomosynthesis project. The tomosynthesis equipment is described as well as the patient selection and image acquisition. Special focus is given to one of the studies of the project, which is a comparison of the diagnostic performance between breast tomosynthesis (BT), digital mammography (DM) and ultrasonography (US): Tumor classification according to the BIR...

In Drosophila melanogaster, the iab-4/iab-8 locus encodes bi-directionally transcribed microRNAs that regulate the function of flanking Hox transcription factors. We show that bi-directional transcription, temporal and spatial expression patterns and Hox regulatory function of the iab-4/iab-8 locus are conserved between fly and the beetle Tribolium castaneum. Computational predictions suggest i...

Computing the exact ideal and nadir criterion values is a very ‎important subject in ‎multi-‎objective linear programming (MOLP) ‎problems‎‎. In fact‎, ‎these values define the ideal and nadir points as lower and ‎upper bounds on the nondominated points‎. ‎Whereas determining the ‎ideal point is an easy work‎, ‎because it is equivalent to optimize a ‎convex function (linear function) over a con...

Focusing on the working relationship between Marketing Managers and Sales Managers, our study examines two dimensions of interpersonal conflict: dysfunctional conflict and functional conflict. Drawing on relevant theory, we include three communication variables – frequency, bidirectionality, and quality – as antecedents in our structural model. Using these explanatory variables we predict the t...

Impaired scavenger receptor class B type I (SR-BI)-mediated uptake of HDL-cholesterol esters (HDL-CE) induces adrenal insufficiency in mice. Humans contain an alternative route of HDL-CE clearance, namely through the transfer by cholesteryl ester transfer protein (CETP) to apolipoprotein B lipoproteins for subsequent uptake via the LDL receptor. In this study, we determined whether CETP can com...

BaBiO3 is a material where formally Bi 4+ ions with the half-filled 6s-states form the alternating set of Bi and Bi ions resulting in a charge ordered insulator. The charge ordering is accompanied by the breathing distortion of the BiO6 octahedra (extension and contraction of the Bi-O bond lengths). Standard Density Functional Theory (DFT) calculations fail to obtain the crystal structure insta...