The phenomenon of molecular binding, where two molecules, referred to as a receptor and ligand, bind together form ligand-receptor complex, is ubiquitous in biology essential for the accurate functioning all life-sustaining processes. probability single forming complex with any one L surrounding ligand molecules at thermal equilibrium can be derived from partition function obtained Gibbs-Boltzm...

Cell adhesion on a supported lipid bilayer (SLB) functionalized with ligand proteins is widely-used cell-mimetic model for the study of trans receptor-ligand interaction that mediates adhesion, and has been shown to play an important role in unravelling molecular players cell adhesion. Experimental studies such cell-SLB systems often assume there no cis interactions between ligands. An question...

A new theory of ligand-receptor bonds in biological cells that accounts for membrane fluctuations reveals an orders-of-magnitude increase binding rates and the range over which a receptor can recognize its ligand.

a pvc membrane ni(ii) ion selective electrode has been constructed using (1e,2e)-bis(2-aminophenyl)n'1,n'2-dihydroxyethanebis as membrane carrier. the electrode exhibited a goodpotentiometric response for ni(ii) over a wide concentration range 1.0×10-4 to 1.0×10-1m with aslope of 29.4±0.5 mv/decade a and a working ph range of 6.5-9.0. it had a fast response time of≤20s. the best performance was...

synthesis and cation selectivity of 25, 27, dipropoxy-26, 28, di-propoxy 5, 11, 17, 23, ptert-butyl calix[4]arene are studied in acetonitrile solution. the stability constants of differentcomplexes of calixarene (as a ligand) with alkali metal cations are determined at 25 °c by usingspectrophotometric technique.on the basis of calculations, complexation of calixarene with cs+and li+ are more fa...

a pvc membrane ni(ii) ion selective electrode has been constructed using (1e,2e)-bis(2-aminophenyl)n'1,n'2-dihydroxyethanebis as membrane carrier. the electrode exhibited a goodpotentiometric response for ni(ii) over a wide concentration range 1.0×10-4 to 1.0×10-1m with aslope of 29.4±0.5 mv/decade a and a working ph range of 6.5-9.0. it had a fast response time of≤20s. the best perfo...

the present work describes the studies on the coordination behaviour of 4[n-(benzalidene) amino]antipyrine semicarbazone (baaps) (i), 4[n-(furfural)amino]antipyrine semicarbazone (ffaaps) (ii) and 4[n-(cinnamalidene)amino]antipyrine semicarbazone (caaps) (iii) in presence of dimethyl sulfoxide (dmso) or diphenyl sulfoxide (dpso) towards th4+ and uo22+ salts. all the complexes were isolated in n...

aromatase inhibitors (ais) as effective candidates have been used in the treatment of hormone-dependent breast cancer. in this study, we have proposed 300 structures as potential ais and filtered them by lipinski’s rule of five using druglito software. subsequently, they were subjected to docking simulation studies to select the top 20 compounds based on their gibbs free energy changes and also...

Herein, the pyridinophane tetradentate ligand PyNMe 3 is used to isolate and structurally characterize well-defined organometallic Ni( ii ) iii complexes bearing cycloneophyl fragment, an alkyl/aryl C-donor ligand.