We present an optical mode solver for a whispering gallery resonator coupled to an adjacent arbitrary shaped nano-particle that breaks the axial symmetry of the resonator. Such a hybrid resonator-nanoparticle is similar to what was recently used for bio-detection and for field enhancement. We demonstrate our solver by parametrically studying a toroid-nanoplasmonic device and get the optimal nan...

The advancement of techniques that can probe the behaviour of individual nanoscopic objects is of paramount importance in various disciplines, including photonics and electronics. As it provides images with a spatiotemporal resolution, four-dimensional electron microscopy, in principle, should enable the visualization of single-nanoparticle structural dynamics in real and reciprocal space. Here...

The suitability of magnetic nanoparticles (MNPs) to act as heat nano-sources by application of an alternating magnetic field has recently been studied due to their promising applications in biomedicine. The understanding of the magnetic relaxation mechanism in biocompatible nanoparticle systems is crucial in order to optimize the magnetic properties and maximize the specific absorption rate (SA...

Nanoparticles are of long-standing interest for the treatment of neurological diseases such as glioblastoma. Most past work focused on methods to introduce nanoparticles into the brain, suggesting that reaching the brain interstitium will be sufficient to ensure therapeutic efficacy. However, optimized nanoparticle design for drug delivery to the central nervous system is limited by our underst...

Nanotechnology a developing field of Science and Technology will leave no field untouched by its ground breaking scientific innovations. The agricultural industry is no exception. So far, the use of nanotechnology in agriculture has been mostly theoretical, but it has begun and will continue to have a significant effect in the main areas of the food industry: development of new functional mater...

We report a novel purification system for 6 His-tagged proteins by magnetic affinity separation. We have developed superparamagnetic Fe3O4@SiO core-shell particles with immobilized surface iminodiacetate groups to chelate with Ni. This Ni magnetic silica nanoparticle has been shown as an efficient carrier, binder and anchor to obtain his-tagged protein directly from total cell lysate. The struc...

Nanoscale objects are typically internalized by cells into membrane-bounded endosomes and fail to access the cytosolic cell machinery. Whereas some biomacromolecules may penetrate or fuse with cell membranes without overt membrane disruption, no synthetic material of comparable size has shown this property yet. Cationic nano-objects pass through cell membranes by generating transient holes, a p...

We have previously proposed a method of treating solid tumors with a combination of gold macro-rods irradiated with ultrasound. Macro particle sized rods offer a greater circumferential treatment area over nanoparticle options. Experimental studies were conducted to investigate the heat enhancement and the bio-heat transfer to breast chicken using gold macro rod and ultrasound. An ultrasound, o...

Biomedical polymer-silicate nanocomposites have potential to become critically important to the development of biomedical applications, ranging from diagnostic and therapeutic devices, tissue regeneration and drug delivery matrixes to various biotechnologies that are inspired by biology but have only indirect biomedical relation. The fundamental understanding of polymer-nanoparticle interaction...

Image guided technique is playing an increasingly important role in the investigation of the biodistribution and pharmacokinetics of drugs or drug delivery systems in various diseases, especially cancers. Besides anatomical imaging modalities such as computed tomography (CT), magnetic resonance imaging (MRI), molecular imaging strategy including optical imaging, positron emission tomography (PE...