ARTICLE INFO Abstract Article History Received: 2 October 2014 Accepted: 2 January 2015 Bioactive glasses are silicate-based and can form a strong chemical bond with the tissues. These biomaterials are highly biocompatible and can form a hydroxyapatite layer when implanted in the body or soaked in the simulated body fluid. Due to several disadvantages, conventional glass processing method inclu...

This work investigated the effect of adding nanoparticulate (29 nm) bioactive glass particles on the bioactivity, degradation and in vitro cytocompatibility of poly(3-hydroxybutyrate) (P(3HB)) composites/nano-sized bioactive glass (n-BG). Two different concentrations (10 and 20 wt %) of nanoscale bioactive glass particles of 45S5 Bioglass composition were used to prepare composite films. Severa...

The bioactive glasses have been used in the medical field due to their wide spread benefits as implant coatings, bone substitutes and for treatment of dentine sensitivity. The purpose of this study was to incorporate zinc and fluoride in the bioactive glass for potential use in dentifrices as antibacterial and anticaries agents. A series of glass compositions based on SiO2, CaO, CaF2, MgO, and ...

Sara Nganga. Development of porous glass-fiber reinforced composite for bone implants. Evaluation of antimicrobial effect and implant fixation. Department of Biomaterials Science, Institute of Dentistry, University of Turku. Annales Universitas Turkuensis, Turku, Finland, 2013. Cranial bone reconstructions are necessary for correcting large skull bone defects due to trauma, tumors, infections a...

The bioactive glass 45S5 was crystallized to 8-100 vol % of crystals by thermal treatments from 550-680 degrees C. The micro-structure of the glass-ceramics had a very uniform crystal size, ranging from 8 to 20 microns. Fourier-transform infrared (FTIR) spectroscopy was used to determine the rate of hydroxycarbonate apatite (HCA) formation that occurs on bioactive glass and glass-ceramic implan...

In this work, the role of shock-wave (SW)-induced increase of bone morphogenetic proteins (BMPs) in modulating the osteogenic properties of osteoblast-like cells seeded on a bioactive scaffold was investigated using gremlin as a BMP antagonist. Bone-like glass-ceramic scaffolds, based on a silicate experimental bioactive glass (CEL2) developed at the Politecnico di Torino, were produced by the ...

Bioactive glass nanoparticles (BG-NPs), based on both ternary (SiO(2)-CaO-P(2)O(5)) and binary (SiO(2)-CaO) systems, were prepared via an optimized sol-gel method. The pH of preparation and the effect of heat treatment temperature were evaluated, as well as the effect of suppressing P in the bioactivity ability of the materials. The morphology and composition of the BG-NPs were studied using FT...

The key research and development steps for bioactive glass (45S5 Bioglass) are documented from the date of discovery in 1969 through FDA approvals of the first dental, ENT, maxillo-facial and orthopedic clinical products. Understanding the mechanisms and quantifying the rapid surface reactions to form a bone-bonding hydroxyl-carbonate apatite (HCA) layer on the bioactive glass in contact with l...

Hollow bioactive glass spheres with mesoporous shells were prepared by using dual soft templates, a diblock co-polymer poly(styrene-b-acrylic acid) (PS-b-PAA) and a cationic surfactant cetyltrimethylammonium bromide (CTAB). Hollow mesoporous bioactive glass (HMBG) spheres comprise the large hollow interior with vertical mesochannels in shell, which realize large uptake of drugs and their sustai...

The interfacial characteristics between bioactive glass (45S5 Bioglass) surfaces and poly(α-hydroxyacid) melts have been assessed by direct wetting measurements. In particular, the wettability of Bioglass powder by poly(D,Llactide) (PDLLA) and poly(D,L-lactide-co-glycolide) (PLGA) was assessed by imbibition measurements. Additionally, the equilibrium contact angles of PDLLA and PLGA melts on a ...