5-Fluorouracil (5-FU) is now used in eye drops for the management of conjunctival malignant melanoma, intraepithelial neoplasia, and corneal squamous cell carcinoma. The previously methods 5-FU quantification AqH were time-consuming less sensitive. Herein, a highly perceptive bioanalytical UPLC–MS/MS method was developed quantitative determination aqueous humor (AqH) rabbits using allopurinol a...

Antibody drug conjugates (ADCs) have grown extremely popular in the pharma industry with 238 clinical trials testing 47 unique ADCs in 20141, but these are complex molecules that need careful development of a bioanalytical strategy to inform the clinical team as to the exposure, safety, and risk profiles of the dosed molecule. This article will highlight some of the key bioanalytical strategies...

The breakthrough in soft ionization methods for biopolymers, electrospray ionization (ESI) and matrix-assisted laser desorption/ionization (MALDI) (1,2), revolutionized mass spectrometry (MS). As a result of these effective bioanalytical technologies, the entire field of proteomics changed, and the use of mass spectrometers for protein identification by accurate mass measurements or de novo seq...

We would like to invite you to participate in the Analytical Challenge, a series of puzzles to entertain and challenge our readers. This special ABC feature has established itself as a truly unique quiz series, with a new scientific puzzle published every other month. Readers can access the complete collection of published problems with their solutions on the Analytical and Bioanalytical Chemis...

Analytical methodologies are critical throughout the medicine development process, including marketing and post-marketing studies. The advancement of bio-analytical techniques has resulted in a dynamic field with many exciting potentials for further future. Bio-analysis is commonly utilised pharmaceutical drug drug's its metabolites' quantitative levels. goal to undertake pharmacokinetic pharma...

Objective: This study aims to develop and validate a simple, rapid accurate HPLC method for the determination of rosmarinic acid (RA), an active marker Thunbergia laurifolia (TL) tea, in Hank's Balanced Salt Solution (HBSS) using HPLC.
 Methods: The separation was performed Xterra® C18 reversed-phase column (150 3.9 mm, 5 µm). mobile phase consisted 0.5% (v/v) glacial acetic (A) acetonitri...

Bioanalytical methods are used to create a protocol that can identify and quantify bioactive molecules their metabolites in human animal samples. For determining the medication its present human/animal body, bioanalytical method is efficient. One of prominent roles creating new techniques, validating existing processes, analyzing Most importantly, compound be calculated using many also detected...