Microneedles were first conceptualized for drug delivery many decades ago, overcoming the shortages and preserving the advantages of hypodermic needle and conventional transdermal drug-delivery systems to some extent. Dissolving and biodegradable microneedle technologies have been used for transdermal sustained deliveries of different drugs and vaccines. This review describes microneedle geomet...

This paper reports microfluidic chip based wet spinning of biodegradable polymers with simple mechanism, and study of cell orientation dependence with fiber size. Biodegradable polymer PLGA fiber was produced by microfluidic chip based spinning device. By controlling feed rate of core polymer and sheath coagulating solutions, we got various PLGA fiber diameter from 10 to 242 μm. L929 mouse fibr...

Biodegradable polymers have attracted a lot of attention in the recent years. These biopolymers are large macromolecules composed of single, repeating monomer units. They are of very high molecular weight and their material characteristics vary according to the nature of their monomer composition. Over the last decade, depletion in the petroleum reserves has resulted in the emergence of biodegr...

A review is given of the development of the concept of an artificial tympanic membrane. Starting with homologous tympanic membranes we compared biodegradable collagen materials (homologous and heterologous) and biodegradable synthetic materials, poly-glycolic acid, poly-lactic acid and poly-alpha-amino acids. As a non-degradable material microporous PTFE and bisphenol-A poly (carbonate) were in...