The advanced bioinformatics technologies are accepted for usefulness in medicine and public health. It can be useful for diagnosis, treatment and prevention of disease. The neuroinformatics is a specific subject of bioinformatics dealing with omics technology for neurology. Several new software and computation tools are developed for serving as databases as well as simulation tools in neuroinfo...

In silico approaches have been widely recognised to be useful for drug discovery. Here, we consider the significance of available databases of medicinal plants and chemo- and bioinformatics tools for in silico drug discovery beyond the traditional use of folk medicines. This review contains a practical example of the application of combined chemo- and bioinformatics methods to study pleiotropic...

In this paper we present a Basic Bioinformatics Meta-searcher (BBMS), a web-based service aiming to simplify and integrate biological data searching through selected biological databases. BBMS facilitates biological data searching enabling multiple sources transparently, increasing research productivity as it avoids time consuming learning and parameterization of different search engines. As a ...

Summary Counting all k -mers in a given dataset is a standard procedure in many bioinformatics applications. We introduce KMC3, a significant improvement of the former KMC2 algorithm together with KMC tools for manipulating k -mer databases. Usefulness of the tools is shown on a few real problems. Availability and implementation Program is freely available at http://sun.aei.polsl.pl/REFRESH/k...

MOTIVATION Circular dichroism (CD) spectroscopy has become established as a key method for determining the secondary structure contents of proteins which has had a significant impact on molecular biology. Many excellent mathematical protocols have been developed for this purpose and their quality is above question. However, reference database sets of proteins, with CD spectra matched to seconda...

The field of bioinformatics has experienced rapid development during the last few years. The volume of data generated at universities and private firms has created a new problem for the bioinformatics researcher: how to retrieve the data from several distributed, heterogeneous databases and how to ensure that the retrieved data is securely transmitted in a computationally efficient fashion. Sev...

This dissertation is concerned with bioinformatics data integration. The first chapter illustrates the current state of biological pathway databases in general, and in particular, plant pathway databases. Key studies are cited to illustrate the potential benefits that may come from further research into integration methods. Different models are explored to interface with the various stakeholder...

Background: Metabolic and genomic informatics integrations in organism-specific databases require comprehensive intensive efforts. PathoLogic, a component of the Pathway Tools software package can create complete Pathway/Genome Databases (PGDBs) from sequence annotation files for any organism. This tool predict metabolic pathways using MetaCyc as reference knowledge base. work aimed to apply bi...

GenBank, the EMBL European Nucleotide Archive and the DNA DataBank of Japan, known collectively as the International Nucleotide Sequence Database Collaboration or INSDC, are the three most significant nucleotide sequence databases. Their records are derived from laboratory work undertaken by different individuals, by different teams, with a range of technologies and assumptions and over a perio...