Heterogeneity in the clinical behavior of chronic lymphocytic leukemia (CLL) patients makes it difficult for physicians to accurately identify which patients may benefit from an early or more aggressive treatment strategy and to provide patients with relevant prognostic information. Given the potential efficacy of newer therapies and the desire to treat patients at “optimum” times, it is more i...

In September 1994, Harris et al' published their Proposal for a Revised European-American Classification of Lymphoid Neoplasms. We have found their report extremely useful for practical work and consider i t a great step forward in the understanding of the biologic behavior of lymphomas for the following reasons. (1) They postulated the presumed normal counterpm of the lymphoma cell and also de...

Childhood T-cell precursor acute lymphoblastic leukemia (TCP ALL) is an aggressive disease with a presumably short latency that differs in many biologic respects from B-cell precursor (BCP) ALL. We therefore addressed the issue of in utero origin of this particular type of leukemia by tracing oncogenic mutations and clone-specific molecular markers back to birth. These markers included various ...

BACKGROUND Receptor occupancy, or saturation, assays are often utilized in preclinical and clinical development programs to evaluate the binding of a biologic to a cellular target. These assays provide critical information regarding the dose of drug required to "saturate" the target as well as important pharmacodymamic (PD) data. A flow cytometric method was developed to measure the degree of S...

Heterogeneity in the clinical behavior of patients with chronic lymphocytic leukemia (CLL) makes it difficult for physicians to accurately identify which patients may benefit from an early or more aggressive treatment strategy and to provide patients with relevant prognostic information. Given the potential efficacy of newer therapies and the desire to treat patients at "optimum" times, it is m...

Abstract Glioblastoma (GBM) is the most common and malignant primary brain tumor with pre-necrotic post-necrotic growth phases. The development of necrosis associated extensive micro-environmental (TME) rearrangement rapid biologic advancement. Compared to GBMs, GBMs are heterogenous contain multi-focal regions surrounded by pseudopalisading cells characterized severe hypoxia. Hypoxic, peri-nec...

abstract : the crown-root fracture is a common tooth injury which compromises the biological width and need proper endodontic and prosthodontic treatment to achieve acceptable clinical outcome. this case report describes clinical management of crown-root fracture in maxillary central incisors which was successfully treated by forceps eruption with 180˚ rotation to restore the biological width. ...

soft tissue-implant interface is an important anatomical feature contributing to the long-term success of dental implants. based on the available evidence, different factors may influence biological width around implants including the surgical technique, implant loading, implant surface properties, abutment materials, implant position, and width of the peri-implant mucosa. the purpose of the pr...

The development of non-manipulative molecular tools to determine the origin of parasite infections in the animal trade (if infected before their export or import) is of great interest worldwide for both the animal trade industry and for animal welfare. Molecular tools have a wide range of applications, including forensic identification, wildlife preservation and conservation, veterinary public ...

Pathologic reviews and clinical studies demonstrate that groups with increased cancer risk can be identified. It is estimated that about 3.5 per cent of colorectal cancers in this country are the result of known heritable cancer syndromes, such as familial polyposis. Much effort is currently being devoted to evaluation of biologic markers, such as cell surface antigens and their antibodies, orn...