INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1004 R I. AN INTRODUCTORY WORD, MAINLY CONCERNING SCOPE . . . 1004 R II. FDA REGULATION’S ORIGINS AND DEVELOPMENT. . . . . . . . . . 1007 R III. ANALYSIS OF REGULATORY COMPLIANCE’S RELEVANCE. . . . . . 1010 R A. The Relevance Traditionally Accorded Regulatory Compliance . . . . . . . ....

Functional stability limits (FSLs) are the percentage of the base of support that individuals are willing to extend their centre of pressure. The objective of this study was to provide construct validation of FSLs as a measure of balance by comparing FSLs across ages and with clinical balance measures. A total of 52 participants volunteered. FSLs significantly decreased with age (p < 0.004). Co...

Possibilities and limitations in the biomechanical analysis of countermovement jump performance were examined using force plate data. Four male and 4 female sport students participated in the study. Software designed to test jumping performance was used to evaluate recordings from a force plate and to compute net velocity and net displacement measures for the center of gravity. In parallel, a f...

of amitriptyline is reported.The disease process was accompanied by noticeable loss of lung compliance, and a gross diffusion defect at alveolar level. It seems unlikely that the course was that of an aspiration or bronchopneumonia, and clinically and pathologically it resembled the changes seen in surfactant deficiency. It is suggested that amitriptyline in overdosage may interfere with the pr...

CONTEXT International differences in compliance of patients undergoing hemodialysis are poorly characterized and could contribute to international survival differences. OBJECTIVE To compare international differences in patient compliance with hemodialysis treatments. DESIGN A prospective observational study of patients undergoing hemodialysis in 1995 and a cross-sectional survey of health c...

background: autoregulation of blood flow is a marvelous phenomenon balanc- ing blood supply and tissue demand. although many chemically-based explanations for this phenomenon have been proposed and some of them are commonly used today, biomechanical aspects of this phenomenon was neglected. the biomechanical aspect provides insights to us to model vessel diameter changes more precisely and comp...

Introduction In a broad review, evidence that the corneal biomechanical properties influence the results and outcomes of various ocular measurements and procedures has existed for some time [1,2]. However, assessing the biomechanical properties of corneal tissue in vivo has previously not been possible. With the recent introduction of the Reichert Ocular Response Analyzer (ORA), direct clinical...

Experimental valveless muscular blood pumps (biomechanical hearts) in goats can pump more than 1 L.min(-1), but due to a high pendulum volume, no significant flow contribution to the circulation is gained. Thus valved and valveless biomechanical hearts were compared for efficacy. Heart failure was induced in 5 adult Bore goats by repeated intracoronary embolization. A valved and balloon-equippe...

Identification of a patient at risk of aspiration is a major problem in the rehabilitation of the dysphagic patient. The present methods of diagnosis are based on clinical evaluation or videofluorography or fiberoptic endoscopic examination of swallowing (FEES). Recently, we developed biomechanical techniques for noninvasive quantitative assessment of the dysphagic patient. The purpose of the p...