In Summer 2002, a patient with frequent epistaxis was admitted to the San Gerardo Hospital. Local examination showed a big mass in the nasal fossa. TC and RMN revealed a diffuse erosion of the palatal bone and infiltration of the maxilla. The tumor was removed and histological examination showed a gland carcinoma. The young age of the patient and the need of an adequate bone reconstruction led ...

In this paper we present the current state of our research on simulation of temporal bone surgical procedures. We describe the results of tests performed on a virtual surgical training system for middle ear surgery. The work is aimed to demonstrate how expert surgeons and trainees can effectively use the system for training and assessment purposes. Preliminary kinematic and dynamic analysis of ...

The cases described by Dr. Enzinger typically occurred in the foot and knee of young adults, especially women, and were intimately associated with tendons. The main symptom was a mass associated with pain in half of the cases, usually of long duration. The median age at onset of symptoms was 24 years, and the median age at initial surgery 26 years. All masses were solitary at presentation. No j...

Severe glenoid wear is technically problematic, has a higher complication rate, and inferior results in the setting of shoulder arthroplasty. This paper introduces four basic strategies for treating glenoid erosion with a reverse shoulder arthroplasty which include; 1. eccentric reaming, 2. bone grafting of glenoid, 3. reaming and bone grafting, and 4. using augmented baseplates. The benefits a...

Bone remodeling, a physiological process characterized by bone formation by osteoblasts and bone resorption by osteoclasts, is important for the maintenance of healthy bone in adult humans. Osteoclasts play a critical role in bone erosion and osteoporosis and are bone-specific multinucleated cells generated through differentiation of monocyte/macrophage lineage precursors. Receptor activator of...

Genetic studies have demonstrated that osteoclasts are essential for focal erosion of bone and cartilage as a consequence of chronic pro-inflammatory cytokine production (TNF, IL-1) in inflammatory arthritis. In these inflamed joints, mature osteoclasts differentiate from circulating osteoclast precursors (OCPs) in response to local increased production of RANKL and pro-inflammatory cytokines. ...

OBJECTIVES Although osteoradionecrosis of the mandible is a well known entity, skull base osteomyelitis involving the temporal bone unrelated to otitis externa in patients with multiple myeloma using bisphosphonates has not been reported. We described a new entity of skull base erosion resulting from osteonecrosis, presenting with malignant features in patients using bisphosphonates for multipl...

PURPOSE To present the spectrum of CT and MR findings of glomus tumors of the head and neck successfully treated with radiation therapy. METHODS The patient charts and all CT and MR studies of 24 patients (25 tumors) who had been successfully treated with radiation therapy were retrospectively reviewed. Eighteen patients had pre- and posttreatment imaging studies. Tumor size, internal morphol...

BACKGROUND We aimed to evaluate the clinical and imaging presentations of Langerhans cell histiocytosis (LCH) in the pediatric temporal bone. METHODS This retrospective study included 27 pediatric cases with pathological confirmed LCH of the temporal bone. The clinical and imaging features of the cases were analyzed. The involvement of ossicular chain and otic capsule was also evaluated. RE...

Destruction of articular joints occurs progressively in patients with rheumatoid arthritis (RA). Although the exact aetiology of RA has not been fully elucidated, a large body of evidence supports a role for interleukin-1 (IL-1) in cartilage and bone erosion. In vitro studies suggest that IL-1 can cause cartilage destruction by stimulating the release of matrix metalloproteinases and other degr...