Non-steroidal anti-inflammatory drugs (NSAIDs) including selective cyclo-oxygenase-2 (COX-2) inhibitors are some of the most commonly prescribed medications worldwide. Nonselective cyclo-oxygenase (COX) inhibitors impair bone healing by inhibiting prostaglandin synthesis. The purpose of this study was to evaluate the long-term effect of etoricoxib, a new selective COX-2 inhibitor, on bone heali...

BACKGROUND Various materials and techniques have been developed to facilitate bone healing process and reduce its healing period. In recent studies, it is pointed out that, platelet-rich fibrin (PRF) which is derived autogenously from the own blood of the individuals, increase regeneration and accelerate the healing of the wound, due to the consisting various growing factors. The aim of the exp...

INTRODUCTION The biological process of fracture healing is complex with influences that are both patient-dependent and related to the trauma experienced and stability of the fracture. Fracture healing complications negatively affect the patient's quality of life, even more when fractures occur in the elderly osteoporotic patients. AREAS COVERED In the polytherapy for bone regeneration, a high...

PURPOSE This study aimed to evaluate the effects of fibronectin and oxysterol immobilized on machined-surface dental implants for the enhancement of cell attachment and osteogenic differentiation, on peri-implant bone healing in the early healing phase using an experimental model in dogs. METHODS Five types of dental implants were installed at a healed alveolar ridge in five dogs: a machined-...

Background and purpose - Studies of fracture healing have mainly dealt with shaft fractures, both experimentally and clinically. In contrast, most patients have metaphyseal fractures. There is an increasing awareness that metaphyseal fractures heal partly through mechanisms specific to cancellous bone. Several new models for the study of cancellous bone healing have recently been presented. Thi...

AIM To use a micro-computed tomography (micro-CT) to quantify bone healing at maxillary first molar extraction sites, and test the hypothesis that bone healing is impaired in CD24-knockout mice as compared with wild-type C57BL/6J mice. MATERIALS AND METHODS Under ketamine-xylazine general anaesthesia, mice had either extraction of the right maxillary first molar tooth or sham operation. Mice ...

The development of new strategies to enhance the healing of fractures continues to evolve with the introduction of both locally and systemically delivered compounds. The recent refinement in the use of autologous bone marrow as a bone graft material has brought the field of stem cell biology into orthopaedic practice. New recombinant peptides such as platelet- derived growth factor and teripara...

Large bone defects and non-union fractures, especially in the diaphysis, represent a challenging and complex interaction of mechanical and biological factors. Fortunately, many of these problem fractures can be successfully managed by stabilization and autologous cancellous bone grafting. However, in some patients autologous cancellous bone graft collection can be associated with morbidity, or ...

To fulfill adequately their functions of support, sustentation and protection for the internal organs and guarantee blood calcium homeostasis, bone tissue is in constant remodeling. Alveolar bone, the primary support structure for teeth, is particularly subjected to continuous and fast remodeling associated with tooth eruption and positional adaptations, as well as with the functional demands o...

Large bone defects and non-union fractures, especially in the diaphysis, represent a challenging and complex interaction of mechanical and biological factors. Fortunately, many of these problem fractures can be successfully managed by stabilization and autologous cancellous bone grafting. However, in some patients autologous cancellous bone graft collection can be associated with morbidity, or ...