E-Cadherin is a transmembrane glycoprotein that mediates Ca2+-dependent intercellular adhesion in normal epithelium. In tumors of epithelial origin, E-cadherin expression frequently is reduced, an event that contributes to tumor invasion and metastasis. The role of E-cadherin in hematopoietic tissues is less clear. In normal bone marrow, E-cadherin is expressed on erythroid progenitors, CD34+ s...

introduction: we aimed at evaluating the clinical, laboratory and echocardiography effects of intracoronary administration of autologous bone marrow stem cell transplantation in different clinical entities of chronic heart failure (hf) patients.   methods: this procedure was carried out during an interventional study conducted in the cardiology department from jan 2012 to apr 2013. the hf patie...

up-regulation of cd4+cd25+cd127low/- regulatory t cells (tregs) is a new target in the treatment of asthma. human bone marrow mesenchymal stem cells can up-regulate cd4+cd25+cd127low/- regulatory t cells in vitro,  meanwhile, heme oxygenase-1 (ho-1) plays an important role in the development and maintenance of cd4+cd25+ regulatory t cells. however the mechanism has not yet been adequately under...

Background:  Renal transplantation is the best choose in the end stage renal disease (ESRD), and acute rejection and graft dysfunction remain major challenges in the worldwide, even with the advent of new immunosuppressive drugs. The novel cell-based anti-rejection treatments have been studied by using different stem cell sources. In this study, transplantation of autologous-bone-marrow-derive...

Paget's disease of bone (PDB) is a chronic localized bone disorder in an elderly population. Environmental factors such as paramyxovirus are implicated in PDB and measles virus nucleocapsid protein (MVNP) has been shown to induce pagetic osteoclasts (OCLs). However, the molecular mechanisms underlying MVNP stimulation of OCL differentiation in the PDB are unclear. We therefore determined the MV...

Several techniques are available for the serological analysis of antigenic determinants on human hematopoietic progenitor cells (HPC). However, techniques for the recognition of cellularly defined antigens on such progenitor cells have not yet been described. We therefore developed an in vitro cellular cytotoxicity assay, with bone marrow cells as target cells. In this assay specific cytotoxic ...

Background: This article reviews experimental and clinical studies in which neural injuries repaired with bone marrow stromal cells. History: Bone marrow contains two kinds of stem cells: hematopoietic and nonhematopoietic (stromal) stem cell. In vitro studies indicate that bone marrow stromal cells have the capacity of differentiation into other cells (such as neural cell) under treatment wit...

introduction: there are the evidences to suggest that bone marrow stromal cells (bmscs) not only differentiate into mesodermal cells, but also adopt the fate of endodermal and ectodermal cell types. bmscs can be a valuable cell source as an autograph for clinical application involving regeneration of the central nervous system. bone marrow stromal cells can be expanded rapidly in vitro and have...

Forty patients with aplastic anemia who were being considered for bone marrow transplantation were studied by in vivo and in vitro techniques to determine if the immune system in aplastic anemia is generally affected. It was found that patients with aplastic anemia had mild lymphopenia. with levels of circulating thymus-derived and bone-marrow-derived cells that were apparently secondarily depr...