BACKGROUND Human mesenchymal stem cells are potential agents for tissue regeneration, enhancing hematopoietic stem cell transplantation and delivering genes of therapeutic interest. To implement any of these strategies successfully, we need a better understanding of factors that influence the tissue distribution of systemically administered mesenchymal stem cells. DESIGN AND METHODS The prese...

Bone marrow microenvironment is fundamental for hematopoietic homeostasis. Numerous efforts have been made to reproduce or manipulate its activity to facilitate engraftment after hematopoietic stem cell transplantation but clinical results remain unconvincing. This probably reflects the complexity of the hematopoietic niche. Recent data have demonstrated the fundamental role of stromal and myel...

The bone marrow serves as a reservoir for different classes of stem cells. In addtion to haematopoietic stem cells the bone marrow comprises a population of marrow stromal cells or mesenchymal stem cells (MSCs). Stromal cells exhibit multilineage differentiation capacity, and are able to generate progenitors with restricted developmental potential, including fibroblasts, osteoblasts, adipocytes...

Background: This article reviews experimental and clinical studies in which neural injuries repaired with bone marrow stromal cells. History: Bone marrow contains two kinds of stem cells: hematopoietic and nonhematopoietic (stromal) stem cell. In vitro studies indicate that bone marrow stromal cells have the capacity of differentiation into other cells (such as neural cell) under treatment wit...

Stem cell-based cellular therapy is a promising tool for the treatment of pathological conditions with underlying severe tissue damage or malfunction like in chronic cardiovascular, musculoskeletal, inflammatory conditions. One biggest technical challenges use natural stem cells, however, prevention their premature senescence during therapeutical manipulations. Culturing cells under hypoxic bel...

Comment on: Jiang et al. Gene expression profiling suggests a pathological role of human bone marrow-derived mesenchymal stem cells in aging-related skeletal diseases. Aging 2011; this issue. In this issue of Impact Aging, Jiang et al. report key differences in the patterns of expressed mRNAs in bone-marrow mesenchymal stem cells (bmMSCs) of young donors compared with old human donors.

Cell therapy using stem cell transplantation against cerebral ischemia has been reported. However, it remains controversial regarding the optimal time for cell transplantation and the transplantation route. Rat models of cerebral ischemia were established by occlusion of the middle cerebral artery. At 1, 12 hours, 1, 3, 5 and 7 days after cerebral ischemia, bone marrow mesenchymal stem cells we...

Mesenchymal stem cells (MSCs) show high expression of PD-L1. Exosomes can transmit signals between tumor and stromal cells; however, the effect tumor-derived exosomes on cell signaling pathways is unclear. The PD-L1 in bone marrow mesenchymal (BMMSCs) was detected by western blot RT-PCR. effects gastric cancer line-derived BMMSC migration conditioned medium from educated BMMSCs were analyzed. O...

stem cell therapy has been applied for the treatment of degenerative diseases encompassing corneal disorders.this consideration is regarding the unique characteristics of stem cells including self-renewal and pluripotency. some corneal diseases result from deficiencies in the limbal region. in these conditions, limbal stem cell therapy is considered in which limbal stem cells are cultured in vi...