Mechanical loading plays a key role in altering macroscopic and microscopic bone structure through functional adaptation; however, the anisotropic micro-organization of collagen and biological apatite (BAp) in adaptively created bone tissue is not well understood in spite of its importance in the mechanical function of bone. In this study, we artificially applied axial compressive loading (15N ...

UNLABELLED To examine the link between bone material properties and skeletal fragility, we analyzed the mechanical, histological, biochemical, and spectroscopic properties of bones from a murine model of skeletal fragility (SAMP6). Intact bones from SAMP6 mice are weak and brittle compared with SAMR1 controls, a defect attributed to reduced strength of the bone matrix. The matrix weakness is at...

To enhance preventative and therapeutic strategies for metabolic bone diseases and bone fragility disorders, we began to explore the physical properties of bone tissue at the cellular level. Proximal femurs were harvested from 27 cadavera (16 male and 11 female) for in vitro measurement of the mechanical properties. We measured the variations in lamellar-level elastic modulus and hardness in hu...

Bone cements produced by different manufacturers vary in their mechanical properties and antibiotic elution characteristics. Small changes in the formulation of a bone cement, which may not be apparent to surgeons, can also affect these properties. The supplier of Palacos bone cement with added gentamicin changed in 2005. We carried out a study to examine the mechanical characteristics and anti...

Reference point indentation (RPI) was developed as a novel method to assess mechanical properties of bone in vivo, yet it remains unclear what aspects of bone dictate changes/differences in RPI-based parameters. The main RPI parameter, indentation distance increase (IDI), has been proposed to be inversely related to the ability of bone to form/tolerate damage. The goal of this work was to explo...

Computational models are employed as tools to investigate possible mechano-regulation pathways for tissue differentiation and bone healing. However, current models do not account for the uncertainty in input parameters, and often include assumptions about parameter values that are not yet established. The aim was to clarify the importance of the assumed tissue material properties in a computati...

a bionanocomposite film was developed by nanoclay incorporation to chitosan films, using a solution casting method and the effects of nanoclay concentration (0.5, 1.0, and 3% w/w) on the physical and mechanical properties of the chitosan films were evaluated. moreover, x-ray diffraction (xrd), scanning electron microscopy, and fourier transform infrared spectra (ftir) were used for studying mic...

this study was conducted to investigate the effects of applying methods andamount of ammonium polyphosphate (0, 2 and 4 wt%) on fire retardancy andmechanical properties of wood flour/polypropylene composites. the resultsshowed that addition of fire retardant improved the mechanical properties such astensile and flexural strengths and fire retardancy of composites. but by increasingof fire retar...

objecttive(s): despite the poor mechanical properties of hydroxyapatite, its unique biological properties leads we think about study on improving its properties rather than completely replacing it with other biomaterials. accordingly, in this study we introduced hydroxyapatite reinforced with hardystonite as a novel bio-nanocompositeand evaluate its in-vitro bioactivity with the aim of developi...

Tendon-to-bone healing is typically poor, with a high rate of repair-site rupture. Bone loss after tendon-to-bone repair may contribute to poor outcomes. Therefore, we hypothesized that the local application of the osteogenic growth factor bone morphogenetic protein 2 (BMP-2) would promote bone formation, leading to improved repair-site mechanical properties. Intrasynovial canine flexor tendons...