UNLABELLED Anti-resorptive and anabolic agents are often prescribed for the treatment of osteoporosis continuously or sequentially for many years. However their impact on cortical bone quality and bone strength is not clear. METHODS Six-month old female rats were either sham operated or ovariectomized (OVX). OVX rats were left untreated for two months and then were treated with vehicle (Veh),...

INTRODUCTION The study of tennis players allows the nonracket arm to act as an internal control for the exercising racket arm. In addition, the study of the upper limbs removes the influence of gravitational loading, allowing the examination of the influence of muscular force on bone adaptation. METHODS The role of muscular action on bone, strength parameters of the radius, ulna (both at 4% a...

Although bone strength and modulus are known to be influenced by both volume fraction and mineral content (ash fraction), the relative influence of these two parameters remains unknown. Single-parameter power law functions are used widely to relate bone volume or ash fraction to bone strength and elastic modulus. In this study we evaluate the potential for predicting bone mechanical properties ...

background: appropriate endurance exercise can change bone mass density and strength of weight-bearing bones in both animals and humans, but its effects on the microstructure are not known. this study aimed to determine skeletal changes induced by the treadmill running endurance in ovariectomized adult mice. methods: twenty-seven adult female rats were divided into experimental and control grou...

The human bone is multiphase material consisting of collagenous matrix interspread with mineral crystals. Magnesium participates in the normal formation and remodelling of bone. Magnesium deficiency has been associated with a number of clinical disorders including osteoporosis. The present investigation focuses on quantitative estimation of magnesium, an inorganic constituent of bone and determ...

INTRODUCTION AND HYPOTHESIS Some papers have shown that bone mineral density (BMD) may not be accurate in predicting fracture risk. Recently microarchitecture parameters have been reported to give information on bone characteristics. The aim of this study was to find out if the values of volume, fractal dimension, and bone mineral density are correlated with bone strength. METHODS Forty-two h...

All materials undergo an aging process which is characterized essentially by changes of the rigidity (stiffness), of the ability to absorb the stresses (toughness) and then ultimately in the mechanical resistance (strength). Both cortical and trabecular bone undergo a continuous process of structural remodeling with the main aim to preserve their biomechanical properties. An imbalance in this p...

INTRODUCTION Ankylosing spondylitis (AS) is an inflammatory disease associated with new bone formation and an increased risk of osteoporosis and fractures. The negative effects of AS on bone microarchitecture and strength are unclear. Thus, we conducted an observational study to analyze the effect of AS on bone microarchitecture and strength. METHODS Patients with AS (n = 53) and non-AS subje...

CONTEXT Increased mechanical loading can promote the preferential differentiation of bone marrow mesenchymal stem cells to osteoblastogenesis, but it is not known whether long-term bone strength-enhancing exercise in humans can reduce marrow adiposity. OBJECTIVE Our objective was to examine whether bone marrow density (MaD), as an estimate of marrow adiposity 1) differs between young female a...

Diets containing 0.31, 0.39, or 0.47% P on a DM basis were fed to 10, 14, and 13 multiparous Holstein cows, respectively, for a full lactation. Most of the cows (33) were fed similar amounts of P in the previous one or two lactations. The objective was to obtain information on bone integrity after prolonged feeding of different amounts of P. At the end of the experiment, a section (-20 cm) of t...