Purpose: Clinical trials in early breast cancer have suggested that benefits of adjuvant bone-targeted treatments are restricted to womenwith establishedmenopause.We developedmodels thatmimic preand postmenopausal status to investigate effects of altered bone turnover on growth of disseminated breast tumor cells. Here, we report a differential antitumor effect of zoledronic acid (ZOL) in these ...

The association between meningioma and hyperostosis of adjacent calvarium is well established. However, the cause of hyperostosis is still not certain. Various authors in the past have tried to explain this phenomenon by preceding trauma or by bone irritation by the tumor without bone invasion, while some believe it to be because of stimulation of osteoblasts in normal bone by factors secreted ...

Primary myeloid sacrom (MS) is a rare tumor and even more rare in multiple organs with no evidence of bone marrow involvement. This report describes an unusual case of a 19-year-old male presenting scrotal MS with a history of subconjunctival MS, 5 months ago. Bone marrow biopsies showed no evidence of acute leukemia. Despite radiotherapy for first involvement and chemotherapy for second presen...

Establishment of skeletal metastasis involves bidirectional interactions between the tumor cell and the cellular elements in the bone microenvironment. A better understanding of the pathophysiology of bone metastasis will be critical in developing the means to prevent bone metastasis or inhibit its progression. The receptor activator of nuclear factor-kappaB (RANK)/RANK ligand pathway has emerg...

A tumor is a lump or mass of tissue that forms when cells divide uncontrollably. A growing tumor may replace healthy tissue with abnormal tissue.Approach to Bone Tumor diagnosis Back to Basics a. Bone tumors represent a unique group of pathologic conditions for which little time is assigned.Primary bone tumors are comparatively rare and, therefore, physicians rarely accumulate enough experience...

A central mediator of a wide host of target genes, the nuclear factor-KB (NF-KB) family of transcription factors, has emerged as a molecular target in cancer and diseases associated with bone destruction. To evaluate how NF-KB signaling in tumor cells regulates processes associated with osteolytic bone tumor burden, we stably infected the boneseeking MDA-MB-231 breast cancer cell line with a do...

  Introduction: Almost all malignant tumors have the potential to eventually produce bone metastasis. The aim of the current study was to report the distribution pattern and imaging characteristics of bone metastases detected by conventional whole body bone scintigraphy in patients with different types of malignancies and to assess their relationship with the complain...

PURPOSE Clinical trials in early breast cancer have suggested that benefits of adjuvant bone-targeted treatments are restricted to women with established menopause. We developed models that mimic pre- and postmenopausal status to investigate effects of altered bone turnover on growth of disseminated breast tumor cells. Here, we report a differential antitumor effect of zoledronic acid (ZOL) in ...

a case of g iant cell tumor of t he vertebra simulat ing vert ebra plana was reported . t he d i agnos i s o f t he vertebra plana should not be confirmed by t he history of the patient and radiologica l manifestation alone . it can onlybe confirmed by biopsy . bone l esions of the spine i s one of the most di fficul t problems t o diagnosis and t r eat . spinal tumors a r e either primary or m...